Skoči na glavni sadržaj

Izvorni znanstveni članak

Antioxidant Enzymes Activity in Patients with Peripheral Vascular Disease, with and without Presence of Diabetes Mellitus

Marica Jandrić-Balen
Veljko Božikov
Dragica Bistrović
Ivan Jandrić
Jadranka Božikov
Željo Romić
Ivan Balen


Puni tekst: engleski pdf 242 Kb

str. 735-743

preuzimanja: 629

citiraj


Sažetak

The study evaluated antioxidant status in patients with peripheral vascular disease
(PVD), with and without concomitant diabetes mellitus (DM). 211 participants were divided
into standardized 4 groups: patients with PVD and DM (PVD+DM+), patients
with PVD without DM (PVD+DM-), patients without PVD with DM (PVD-DM+) and
patients without PVD and DM (PVD-DM-). The diagnosis of PVD was established by
Doppler sonography analysis, including determination of the ankle brachial index (ABI),
partial pressures along the leg, and CW Doppler sonography at typical locations. Antioxidant
status has been evaluated through the colorimetrically assessed serum activity
of key antioxidant enzymes: superoxide dismutase (SOD), catalase, and glutathione peroxidase
(GLPX) as well as through total antioxidant status (TAS) determination. In
PVD+DM- group, as well as PVD-DM+ group, a significantly lower activity of the GLPX,
catalase and TAS was found, whereas activity of SOD was significantly higher. There
was no statistically significant difference between PVD+DM+ and PVD-DM+ group. Likewise,
there was no statistically significant difference between PVD+DM- and PVD
-DM-group. This study has shown that there is statistically significant difference in activity
of antioxidant enzymes between diabetic and non-diabetic patients, irrespectively
of PVD presence. Furthermore, PVD present alone does not alter key antioxidant enzymes
activity in comparison with healthy subjects.

Ključne riječi

peripheral vascular disease; diabetes mellitus; antioxidant enzymes

Hrčak ID:

28173

URI

https://hrcak.srce.hr/28173

Datum izdavanja:

15.12.2003.

Posjeta: 1.091 *