Original scientific paper
Effect of Helicobacter Pylori Eradication on Extent of Duodenal Gastric Metaplasia and Grade of Gastritis
J. Bago
D. Strinić
Ž. Belošić Halle
D. Jandrić
M. Tomić
A. Bilić
P. Bago
Abstract
The extent of the regression of duodenal gastric metaplasia (DGM) after the eradication
of Helicobacter pylori infection is controversial. Therefore, we decided to assess the
degree of DGM before, sex weeks and one year after H. pylori eradication. 105 consecutive
Helicobacter pylori positive patients with endoscopically proven duodenal ulcer,
with DGM and Helicobacter pylori infection were recruited for this study. The diagnosis
of Helicobacter pylori infection was based on CLO-test and histology, and DGM was assessed
on four bulb biopsies taken before, sex weeks and one year after Helicobacter
pylori eradication. Histological assessment of Helicobacter pylori associated gastritis
was performed according to the Sydney classification. Follow up study on 98 patients
before, six weeks and one year after the eradication of Helicobacter pylori showed that
the mean extent of DGM did not change significantly after eradication and did not differ
when compared with 14 patients with persisting infection. Our results show that the
inflammatory process related to Helicobacter pylori does not play the main role in the
development of DGM.
Keywords
Hrčak ID:
28298
URI
Publication date:
16.12.2002.
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