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Modelling of ICAM-1 and LFA-1 Interaction Using Molecular Recognition Theory

Nikola Štambuk ; Ruđer Bošković Institute, Zagreb, Croatia
Paško Konjevoda ; Ruđer Bošković Institute, Zagreb, Croatia
Dražen Vikić-Topić ; Ruđer Bošković Institute, Zagreb, Croatia
Biserka Pokrić ; Ruđer Bošković Institute, Zagreb, Croatia

Puni tekst: engleski, pdf (80 KB) str. 283-287 preuzimanja: 380* citiraj
APA 6th Edition
Štambuk, N., Konjevoda, P., Vikić-Topić, D. i Pokrić, B. (2008). Modelling of ICAM-1 and LFA-1 Interaction Using Molecular Recognition Theory. Croatica Chemica Acta, 81 (2), 283-287. Preuzeto s https://hrcak.srce.hr/28362
MLA 8th Edition
Štambuk, Nikola, et al. "Modelling of ICAM-1 and LFA-1 Interaction Using Molecular Recognition Theory." Croatica Chemica Acta, vol. 81, br. 2, 2008, str. 283-287. https://hrcak.srce.hr/28362. Citirano 10.04.2020.
Chicago 17th Edition
Štambuk, Nikola, Paško Konjevoda, Dražen Vikić-Topić i Biserka Pokrić. "Modelling of ICAM-1 and LFA-1 Interaction Using Molecular Recognition Theory." Croatica Chemica Acta 81, br. 2 (2008): 283-287. https://hrcak.srce.hr/28362
Harvard
Štambuk, N., et al. (2008). 'Modelling of ICAM-1 and LFA-1 Interaction Using Molecular Recognition Theory', Croatica Chemica Acta, 81(2), str. 283-287. Preuzeto s: https://hrcak.srce.hr/28362 (Datum pristupa: 10.04.2020.)
Vancouver
Štambuk N, Konjevoda P, Vikić-Topić D, Pokrić B. Modelling of ICAM-1 and LFA-1 Interaction Using Molecular Recognition Theory. Croatica Chemica Acta [Internet]. 2008 [pristupljeno 10.04.2020.];81(2):283-287. Dostupno na: https://hrcak.srce.hr/28362
IEEE
N. Štambuk, P. Konjevoda, D. Vikić-Topić i B. Pokrić, "Modelling of ICAM-1 and LFA-1 Interaction Using Molecular Recognition Theory", Croatica Chemica Acta, vol.81, br. 2, str. 283-287, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/28362. [Citirano: 10.04.2020.]

Sažetak
The model of ICAM-1 and LFA-1 molecular interaction was used to test the application of the
Molecular Recognition Theory for the identification of several discontinuous binding regions,
i.e. ligand-receptor sites, within large antigenic molecules. Molecular Recognition Theory is an
applicable heuristic algorithm for identification of possibly interacting amino acid pairs in short
linear epitope/paratope sites within larger molecules. However, in order to achieve better efficiency
this heuristic algorithm of molecular recognition has to be combined to several other
procedures: molecular hydropathy analyses, secondary structure prediction methods and protein
database search. The limitation of the combined MRT-hydropathy analyses is in the fact
that it cannot explain 3D protein interactions, but it can be a valuable starting point for a more
complex computational and experimental analysis.

Ključne riječi
molecular recognition; heuristic algorithm; ICAM-1; LFA-1; binding

Hrčak ID: 28362

URI
https://hrcak.srce.hr/28362

Posjeta: 632 *