Sažetak sa skupa
Periotron as a Modern Sialometric Method in Xerostomia Diagnosis and Treatment Monitoring
I. Alajbeg
N. Hladki
A. Cekić-Arambašin
IŽ. Alajbeg
Sažetak
The Periotron micro-moisture meter (Oraflow, Plainview, USA) is an electronic instrument that has been designed for gingival vrevicular fluid (GCF), periodontal pocket fluid (PPF), salivary flow and saliva thickness measurments, by using a variety of paper collection strips. Collection strips (Periopaper strips, PerioCol strips, Sialopaper strips) are applied to the oral tissues of interest for a certain period of time, after which the are inserted between Periotron electrodes. The special insulation coating on the electrodes enables them to work as two plates of a capacitor, being able to measure submicroliter quantities of oral fluids. Periotron displays the numerical output on LCD. By inputting data obtained during prior calibration process into Periotron professional software for Windows, we design a standard curve, from which we interpolate actual fluid volume. We have designed a single blind placebo controlled study to evaluate possible presence of long-term effect of pilocarpine-hydrocloride (PHC) on salivary flow rate in patients with xerostomia. 12 patients suffering from xerostomia underwent this trial. We used strict inclusion criteria regarding the possible side effects. Six patients were instructed to self-administer 5 mh of PHC (5 drops of solution, Pilokarpin 2%, pliva Zagreb, Croatia), three times a day, for 7 days. Another 6 patients (placebo group) were instructed to take 5 dexapanthenol drops (D panthenol, Ljekarne Zagreb, Zagreb, croatia), 3 times a day for 7 weeks. The flow rate of minor salivary glands was measured on the lower lip and palate by means of Periotron and whole saliva was collected in calibrated test tubes. mesurements were repeated once a week. Each patient filled in an extensive Oral Health Impact Profile questionnaire (OHIP) at te baseline and after completion of PHC treatment to monitor oral health influence on patients lives. After 7 weeks of treatment the placebo group was swiched to PHC, but there no apparent need for switching pilocarpine group to placebo, because we found no improvement in salivary flow rate after 7 weeks of treatment. in the group previously taking placebo, there was also no improvement in salivary flow rate after taking PHC. OHIP findings were calculated and showed no statistically significnt improvement after 7 weeks of PHC administration. One patient from the pilocarpine group and one from palcebo group ( while taking placebo) reported side effects and discontinuited the trial. oral administration of PHC does not seem to produce log-term salivary flow rate increase, but rther immediate and shortr lasting improvement. Judging by Periotron and whole saliva scores, our results showed that PHC is not able to “cure” xerostomia after prolonged administration, i.e. there is no residual effect in salivary gland simulation once the drug is discontinued and eliminated.
Ključne riječi
Hrčak ID:
2899
URI
Datum izdavanja:
15.9.2003.
Posjeta: 2.287 *