hrcak mascot   Srce   HID

Izvorni znanstveni članak

ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA

Jasenka Mršić Pelčić ; Department of Pharmacology, School of Medicine, Rijeka, Croatia
Goran Pelčić ; Clinics for Ophtalmology, University Hospital Centre Rijeka, Rijeka, Croatia
Dinko Vitezić ; Department of Pharmacology, School of Medicine, Rijeka, Croatia
Đulijano Ljubičić ; Clinics for Psychiatry, University Hospital Centre Rijeka, Rijeka, Croatia
Gordana Župan ; Department of Pharmacology, School of Medicine, Rijeka, Croatia
Ante Simonić ; Department of Pharmacology, School of Medicine, Rijeka, Croatia

Puni tekst: engleski, pdf (448 KB) str. 456-460 preuzimanja: 292* citiraj
APA 6th Edition
Mršić Pelčić, J., Pelčić, G., Vitezić, D., Ljubičić, Đ., Župan, G. i Simonić, A. (2008). ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA. Psychiatria Danubina, 20. (4.), 456-460. Preuzeto s https://hrcak.srce.hr/29072
MLA 8th Edition
Mršić Pelčić, Jasenka, et al. "ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA." Psychiatria Danubina, vol. 20., br. 4., 2008, str. 456-460. https://hrcak.srce.hr/29072. Citirano 25.10.2020.
Chicago 17th Edition
Mršić Pelčić, Jasenka, Goran Pelčić, Dinko Vitezić, Đulijano Ljubičić, Gordana Župan i Ante Simonić. "ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA." Psychiatria Danubina 20., br. 4. (2008): 456-460. https://hrcak.srce.hr/29072
Harvard
Mršić Pelčić, J., et al. (2008). 'ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA', Psychiatria Danubina, 20.(4.), str. 456-460. Preuzeto s: https://hrcak.srce.hr/29072 (Datum pristupa: 25.10.2020.)
Vancouver
Mršić Pelčić J, Pelčić G, Vitezić D, Ljubičić Đ, Župan G, Simonić A. ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA. Psychiatria Danubina [Internet]. 2008 [pristupljeno 25.10.2020.];20.(4.):456-460. Dostupno na: https://hrcak.srce.hr/29072
IEEE
J. Mršić Pelčić, G. Pelčić, D. Vitezić, Đ. Ljubičić, G. Župan i A. Simonić, "ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA", Psychiatria Danubina, vol.20., br. 4., str. 456-460, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/29072. [Citirano: 25.10.2020.]

Sažetak
SUMMARY
Objectives: To determine the influence of global cerebral ischemia on the activation of extracellular-regulated kinases (ERK) and c-Jun N terminal kinases (JNK) in optic nerves of rats exposed to different reperfusion periods.
Materials and methods: Transient global cerebral ischemia (20-min duration) was induced by the four-vessel occlusion method. After different reperfusion periods (5 and 10 min; 1; 6 and 12 h after ischemia), optic nerves were extracted and ERK and JNK activation signals were determined by Western immunoblot analyses.
Results: The activation signals of ERK and JNK were detected within first 10 min of reperfusion, but striking activation for both enzymes was found 1 h after ischemia. After a transient decrease, the activation of ERK returned to peak level after 12 h of reperfusion in the second wave of kinase activation. In that period, a slight increase of JNK activation was registered.
Conclusion: Our results demonstrated for the first time that ERK and JNK were activated in rat optic nerves during early and later periods of reperfusion, suggesting their potential active role in the response of cerebral white matter tissue to ischemic injury.

Ključne riječi
ERK; JNK; optic nerves; global cerebral ischemia; rat

Hrčak ID: 29072

URI
https://hrcak.srce.hr/29072

Posjeta: 473 *