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Combined in silico and in vitro Approach to Drug Screening
Puni tekst: engleski, pdf (273 KB)
APA 6th Edition
Verbanac, D., Jelić, D., Stepanić, V., Tatić, I., Ziher, D. i Koštrun, S. (2005). Combined in silico and in vitro Approach to Drug Screening. Croatica Chemica Acta, 78 (2), 133-139. Preuzeto s https://hrcak.srce.hr/3
MLA 8th Edition
Verbanac, Donatella, et al. "Combined in silico and in vitro Approach to Drug Screening." Croatica Chemica Acta, vol. 78, br. 2, 2005, str. 133-139. https://hrcak.srce.hr/3. Citirano 23.07.2018.
Chicago 17th Edition
Verbanac, Donatella, Dubravko Jelić, Visnja Stepanić, Iva Tatić, Dinko Ziher i Sanja Koštrun. "Combined in silico and in vitro Approach to Drug Screening." Croatica Chemica Acta 78, br. 2 (2005): 133-139. https://hrcak.srce.hr/3
Verbanac, D., et al. (2005). 'Combined in silico and in vitro Approach to Drug Screening', Croatica Chemica Acta, 78(2), str. 133-139. Preuzeto s: https://hrcak.srce.hr/3 (Datum pristupa: 23.07.2018.)
Verbanac D, Jelić D, Stepanić V, Tatić I, Ziher D, Koštrun S. Combined in silico and in vitro Approach to Drug Screening. Croatica Chemica Acta [Internet]. 15.06.2005. [pristupljeno 23.07.2018.];78(2):133-139. Dostupno na: https://hrcak.srce.hr/3
D. Verbanac, D. Jelić, V. Stepanić, I. Tatić, D. Ziher i S. Koštrun, "Combined in silico and in vitro Approach to Drug Screening", Croatica Chemica Acta, vol.78, br. 2, str. 133-139, Srpanj 2018. [Online]. Dostupno na: https://hrcak.srce.hr/3. [Citirano: 23.07.2018.]
The purpose of High Throughput Screening (HTS) in pharmaceutical industry is to identify, as soon as possible, compounds that are good starting points for successful new drug development process. Experts from this area study the chemical structures of so called »hit« compounds that have been found to interact with the target protein, interfere with proliferation of different types of cells or stop bacterial or fungal growth. Hypotheses to design related structures with improved biological properties are than builded. Each idea is then tested by the iterative synthesis and testing of novel compounds in various biological assays, searching for hits with better properties and defining useful and promising »lead« molecules. In parallel, molecular modeling and chemoinformatics experts can increase efficiency and decrease experimental costs by using different database filtering methods. In such a way, hits from HTS may be assessed before committing significant resource for chemical optimization. Joint efforts of these HTS experimental and modeling groups are the best way to speed up the process of finding a
new useful hits and promising leads.
clustering; compounds library; drug discovery; in silico; in vitro; screening
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