Veterinarski arhiv, Vol. 93 No. 3, 2023.
Izvorni znanstveni članak
https://doi.org/10.24099/vet.arhiv.1704
Quercetin supports acaricidal activity of ivermectin against naturally acquired sarcoptic mange in pigs
Vivek Joshi
; Division of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India; Animal Health Section, ICAR-National Research Centre on Mithun, Medziphema, Dimapur, Nagaland, India
Umesh Dimri
; Division of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India
Asandi Govindappa Bhanuprakash
; Division of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India
Vinod Kumar Gupta
; Division of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India
Sažetak
Sarcoptic mange triggers continuous oxidative onslaughts, resulting in severe oxidative stress in pigs and, to date, no antioxidant has been evaluated for the treatment of naturally infested pigs. This randomized clinical trial aimed to assess the ameliorative potential of the antioxidant quercetin (QR) when integrated with ivermectin (IVM) in the treatment of sarcoptic mange in pigs. The control group (T0 , n=10) consisted of healthy subjects. The first treatment group (T1 , n=10) consisted of infested pigs receiving the standard treatment (subcutaneous IVM only) while the second treatment group (T2 , n=10) consisted of infested pigs receiving integrated treatment (subcutaneous IVM plus oral QR). On day 0, the circulating malondialdehyde (MDA) was significantly higher and superoxide dismutase (SOD), reduced glutathione (GSH), catalase (CAT), total antioxidant capacity (TAC) and antioxidative minerals (zinc, copper, iron) were lower in all infested pigs compared to the healthy subjects. On day 14 post-treatment, maximum recovery was observed in the MDA, SOD, GSH, CAT, TAC, zinc, copper and iron in group T2 and the results returned to normal earlier in group T2 than in T1 . Likewise, more significant improvements in parasitological cure rate, scratching index and skin score were recorded after treatment in group T2 than group T1 . These results suggest the greater effectiveness of IVM plus QR than IVM alone against sarcoptic mange, and quercetin may be recommended as an ancillary therapy with IVM to negate severe oxidative stress, improve post-therapy convalescence and produce a speedy recovery in pigs.
Ključne riječi
integrated treatment; oxidative stress; pigs; quercetin; sarcoptic mange
Hrčak ID:
307407
URI
Datum izdavanja:
16.8.2023.
Posjeta: 923 *