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Kratko priopćenje
https://doi.org/10.2478/v10007-009-007-x

Macromolecular prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation

ZRINKA RAJIĆ ; Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
GABRIJELA KOS ; Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
BRANKA ZORC ; Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
PRATI PAL SINGH ; National Institute of Pharmaceutical Education and Research, Sector-67, Phase-X, S.A.S. Nagar-160062, India
SAVITA SINGH ; National Institute of Pharmaceutical Education and Research, Sector-67, Phase-X, S.A.S. Nagar-160062, India

Puni tekst: engleski, pdf (88 KB) str. 107-115 preuzimanja: 616* citiraj
APA 6th Edition
RAJIĆ, Z., KOS, G., ZORC, B., SINGH, P.P. i SINGH, S. (2009). Macromolecular prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation. Acta Pharmaceutica, 59 (1), 107-115. https://doi.org/10.2478/v10007-009-007-x
MLA 8th Edition
RAJIĆ, ZRINKA, et al. "Macromolecular prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation." Acta Pharmaceutica, vol. 59, br. 1, 2009, str. 107-115. https://doi.org/10.2478/v10007-009-007-x. Citirano 22.09.2019.
Chicago 17th Edition
RAJIĆ, ZRINKA, GABRIJELA KOS, BRANKA ZORC, PRATI PAL SINGH i SAVITA SINGH. "Macromolecular prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation." Acta Pharmaceutica 59, br. 1 (2009): 107-115. https://doi.org/10.2478/v10007-009-007-x
Harvard
RAJIĆ, Z., et al. (2009). 'Macromolecular prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation', Acta Pharmaceutica, 59(1), str. 107-115. https://doi.org/10.2478/v10007-009-007-x
Vancouver
RAJIĆ Z, KOS G, ZORC B, SINGH PP, SINGH S. Macromolecular prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation. Acta Pharm. [Internet]. 2009 [pristupljeno 22.09.2019.];59(1):107-115. https://doi.org/10.2478/v10007-009-007-x
IEEE
Z. RAJIĆ, G. KOS, B. ZORC, P.P. SINGH i S. SINGH, "Macromolecular prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation", Acta Pharmaceutica, vol.59, br. 1, str. 107-115, 2009. [Online]. https://doi.org/10.2478/v10007-009-007-x

Sažetak
New primaquine conjugates 5-7 with glucosamine and two polymers of polyaspartamide type, poly/a,b-(N-2-hydroxyethyl-DL-aspartamide)/ (PHEA) and poly/a,b-(N-3-hydroxypropyl-DL-aspartamide)/ (PHPA), were synthesized, characterized and screened for their antimalarial activity. The conjugates differed in type of covalent bounding, length of spacer between the polymeric carrier and drug, molecular mass and drug-loading. Blood-schizontocidal activity of the prepared conjugates was tested against Plasmodium berghei infection in Swiss mice. The polymeric conjugates showed better antimalarial activity than glucosamine conjugate.

Ključne riječi
primaquine; polymer-drug conjugate; polyaspartamide; glucosamine; antimalarial activity

Hrčak ID: 31553

URI
https://hrcak.srce.hr/31553

[hrvatski]

Posjeta: 1.023 *