Acta Pharmaceutica, Vol. 59 No. 1, 2009.
Kratko priopćenje
https://doi.org/10.2478/v10007-009-007-x
Macromolecular prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation
ZRINKA RAJIĆ
; Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
GABRIJELA KOS
; Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
BRANKA ZORC
orcid.org/0000-0003-4355-8816
; Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
PRATI PAL SINGH
; National Institute of Pharmaceutical Education and Research, Sector-67, Phase-X, S.A.S. Nagar-160062, India
SAVITA SINGH
; National Institute of Pharmaceutical Education and Research, Sector-67, Phase-X, S.A.S. Nagar-160062, India
Sažetak
New primaquine conjugates 5-7 with glucosamine and two polymers of polyaspartamide type, poly/a,b-(N-2-hydroxyethyl-DL-aspartamide)/ (PHEA) and poly/a,b-(N-3-hydroxypropyl-DL-aspartamide)/ (PHPA), were synthesized, characterized and screened for their antimalarial activity. The conjugates differed in type of covalent bounding, length of spacer between the polymeric carrier and drug, molecular mass and drug-loading. Blood-schizontocidal activity of the prepared conjugates was tested against Plasmodium berghei infection in Swiss mice. The polymeric conjugates showed better antimalarial activity than glucosamine conjugate.
Ključne riječi
primaquine; polymer-drug conjugate; polyaspartamide; glucosamine; antimalarial activity
Hrčak ID:
31553
URI
Datum izdavanja:
1.3.2009.
Posjeta: 2.698 *