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CHANGES OF TSH, FT3 AND FT4 LEVELS IN PATIENTS WITH HYPERTHYROIDISM

Nafija Serdarević orcid.org/0000-0001-7977-9819 ; OJ Klinička biohemija s imunologijom, Klinički Centar Univerziteta u Sarajevu, 71 000 Sarajevo, Bosna i Hercegovina & Fakultet zdravstvenih studija, Univerzitet u Sarajevu; 71 000 Sarajevo, Bosna i Hercegovina *
Marina Ćurlin ; 3 Fakultet zdravstvenih studija, Sveučilište u Mostaru; 88 000 Mostar, Bosna i Hercegovina
Aldijana Dautbašić orcid.org/0009-0006-2586-0068 ; Fakultet zdravstvenih studija, Univerzitet u Sarajevu; 71 000 Sarajevo, Bosna i Hercegovina & Plava Poliklinika, 75 000 Tuzla, Bosna i Hercegovina
Adina Elena Stanciu orcid.org/0000-0002-9494-6686 ; Odjel karcinogeneze i molekularne biologije, Onkološki institut Bukurešt, 252 Fundeni, 022338 Bukurešt, Rumunjska
Dabla Pradeep orcid.org/0000-0003-1409-6771 ; Odjel za biokemiju, G. B. Pant Institut za poslijediplomsko medicinsko obrazovanje i istraživanje (GIPMER), GNCTD, Delhi, Indija
Azra Durak-Nalbantić orcid.org/0000-0002-5175-8941 ; Klinika za srce, krvne žile i reumatske bolesti, Klinički centar Univerziteta u Sarajevu, 71 000 Sarajevo, Bosna i Hercegovina

* Dopisni autor.

Sažetak

Introduction: The thyroid hormone secretion disorders may be hyperthyroidism (reduced TSH levels and increased levels of FT3 and FT4) and subclinical hyperthyroidism (decreased concentration of TSH with normal FT3 and FT4).
Aim: To investigate levels of thyroid hormones (TSH, FT3, and FT4) in patients with hyperthyroidism or subclinical hyperthyroidism treated at Tuzla Blue Clinic.
Materials and methods: The study included 120 patients divided into three groups: a control group, groups with respondents who have hyperthyroidism, and a group of patients with subclinical hyperthyroidism. The concentrations of the hormones TSH, FT3, and FT4 were analyzed. The determination was carried out on the device IMMULITE 1 Siemens using the immunochemistry method.
Results: TSH between our group investigated the existence of significant statistical differences between the control group and the group with hyperthyroidism (p<0.0001) and between the control group hyperthyroidism (p<0.0001) and between groups with hyperthyroidism and subclinical hyperthyroidism (p <0.0001).
Conclusions: The concentration of TSH is reduced in both hyperthyroidism and subclinical hyperthyroidism. The serum concentrations of FT3 and FT4 are elevated in hyperthyroidism, while in subclinical hyperthyroidism, the serum concentrations of FT3 and FT4 stand in the reference area.and the group with subclinical hyperthyroidism (p=0.0001), and the parameter FT3 showed that a statistically significant difference exists between the control group and the group with hyperthyroidism (p<0.0001), and between patients with hyperthyroidism and subclinical hyperthyroidism (p<0.0001). For FT4, we found a statistically significant difference between the control group and the group with hyperthyroidism (p<0.0001) and between groups with hyperthyroidism and subclinical hyperthyroidism (p <0.0001).
Conclusions: The concentration of TSH is reduced in both hyperthyroidism and subclinical hyperthyroidism. The serum concentrations of FT3 and FT4 are elevated in hyperthyroidism, while in subclinical hyperthyroidism, the serum concentrations of FT3 and FT4 stand in the reference area.

Ključne riječi

Thyrotropin; thyroxine; TSH; FT3; FT4; hyperthyroidism

Hrčak ID:

317553

URI

https://hrcak.srce.hr/317553

Datum izdavanja:

28.5.2024.

Podaci na drugim jezicima: hrvatski

Posjeta: 417 *