Medicina Fluminensis, Vol. 61 No. 2, 2025.
Pregledni rad
https://doi.org/10.21860/medflum2025_330052
Clinical Potential of Extracellular Vesicles in Central Nervous System Pathologies
Marin Tota
orcid.org/0000-0002-9131-4587
; University of Rijeka, Faculty of Medicine, Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Rijeka, Croatia
Ana Blagaić
; Clinical Hospital Centre Rijeka, Department of Anaesthesiology and Intensive Care, Rijeka, Croatia
*
David Bonifačić
; Clinical Hospital Center Rijeka, Department of Neurology, Rijeka, Croatia; University of Rijeka, Faculty of Medicine, Department of Neurology, Rijeka, Croatia
* Dopisni autor.
Sažetak
The number of neurological disorders has been increasing for the last 30 years, and they are now among top 10 causes of mortality. As for neurodegenerative diseases in which Alzheimer’s and Parkinson’s disease predominate, there is a very small number of available and mostly symptomatic drugs. It is therefore a priority to find appropriate therapies, as well as biomarkers for early detection and monitoring of such disorders. Extracellular vesicles are formed in almost all cells, they transfer macromolecules like DNA, RNA and proteins to give an image of the tissue from which they originate. This makes them an excellent diagnostic as well as therapeutic tools. Therefore, there is a substantial goal in the need to find an adequate procedure for isolation of vesicles, in order to find a good biomarker from body fluids that does not require invasive methods.
Ključne riječi
biomarkers; central nervous system diseases; extracellular vesicles
Hrčak ID:
330052
URI
Datum izdavanja:
1.6.2025.
Posjeta: 702 *