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Croatian Medical Journal, Vol. 64 No. 1, 2023.

Original scientific paper

https://doi.org/10.3325/cmj.2023.64.37

Importance of numerical density of tubulointerstitium infiltrates in the prognosis of antineutrophil cytoplasmic antibodies-associated glomerulonephritis

Dušan Božić ; Medical Faculty, University of Novi Sad, Novi Sad, Serbia
Bojana Ljubičić ; Medical Faculty, University of Novi Sad, Novi Sad, Serbia *
Violeta Knežević ; Medical Faculty, University of Novi Sad, Novi Sad, Serbia
Dejan Ćelić ; Medical Faculty, University of Novi Sad, Novi Sad, Serbia
Vladimir Veselinov ; Medical Faculty, University of Novi Sad, Novi Sad, Serbia

* Corresponding author.

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Abstract

Aim To examine the association of the numerical density
of the tubulointerstitium infiltrate with pathohistological
changes in the glomeruli and the estimated glomerular filtration rate (eGFR) at kidney biopsy and after 18 months.
Methods This retrospective study enrolled 44 patients
(43.2% male) with antineutrophil cytoplasmic antibodies-associated glomerulonephritis treated at the University Clinical Center of Vojvodina between 2017 and 2020.
The numerical density of infiltrates in the tubulointerstitium was determined with the Weibel (M-2) system. Data
on biochemical, clinical, and pathohistological parameters
were obtained.
Results The mean age was 57.7±10.23 years. Global sclerosis in more than 50% of glomeruli and crescents in more
than 50% of glomeruli were significantly associated with a
mean lower eGFR (17.6±11.78; 32.0±26.13, respectively) at
kidney biopsy (P=0.002; P<0.001, respectively), but not after 18 months. The average numerical density of infiltrates
was significantly higher in patients with more than 50% of
globally sclerotic glomeruli (P<0.001) and with crescents
in more than 50% of glomeruli (P<0.001). The average numerical density of infiltrates significantly correlated with
eGFR at biopsy (r=-0.614), but not after 18 months. Our results were confirmed by using multiple linear regression.
Conclusion Numerical density of infiltrates, and global
glomerular sclerosis and crescents in more than 50% of
glomeruli significantly affect eGFR at biopsy, but not after
18 months.

Keywords

Hrčak ID:

331250

URI

https://hrcak.srce.hr/331250

Publication date:

1.3.2023.

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