Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2023.64.231
Neuroprotective effects of goji berry (Lycium barbarum L.) polysaccharides on depressionlike behavior in ovariectomized rats: behavioral and biochemical evidence
Hayriye Soytürk
; Department of Interdisciplinary Neuroscience, Health Sciences Institute, Bolu Abant Izzet Baysal University, Bolu, Turkey
Bihter Gökçe Bozat
; Department of Interdisciplinary Neuroscience, Health Sciences Institute, Bolu Abant Izzet Baysal University, Bolu, Turkey
Fatma Pehlivan Karakas
; Department of Biology, Faculty of Science and Art, Bolu Abant Izzet Baysal University, Bolu, Turkey
*
Hamit Coskun
; Department of Psychology, Faculty of Science and Art, Bolu Abant Izzet Baysal University, Bolu, Turkey
Tulin Firat
; Department of Histology and Embryology, Faculty of Medicine Bolu Abant Izzet Baysal University, Bolu, Turkey
* Dopisni autor.
Sažetak
Aim To assess the protective effects of goji berry (Lycium
barbarum L.) polysaccharides (LBP) on depression-like behavior in ovariectomized rats and to elucidate the mechanisms underlying these effects.
Methods One hundred female Wistar albino rats (three
months old) were randomly assigned either to ovariectomy (n=50) or sham surgery (n=50). After a 14-day recovery period, the groups were divided into five treatment
subgroups (10 per group): high-dose LBP (200 mg/kg),
low-dose LBP (20 mg/kg), imipramine (IMP, 2.5 mg/kg), 17-
beta estradiol (E2, 1 mg/kg), and distilled water. Then, rats
underwent a forced swimming test. We also determined
the levels of serum antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde), E2 levels, hippocampal brain-derived neurotrophic factor (BDNF), 5HT2A receptor, and transferase
dUTP nick end labeling (TUNEL)-positive cells.
Results Both low-dose LBP and imipramine decreased
depression-like behavior by increasing serum superoxide
dismutase activity and by decreasing serum malondialdehyde level. Furthermore, low-dose LPB, high-dose LBP, and
imipramine increased the number of 5-HT2A receptor- and
BDNF-positive cells but decreased the number of TUNELpositive cells in the hippocampus.
Conclusion This is the first study to show the antidepressant effect of LBP. Although additional research is needed,
LBP may be considered a potential new antidepressant.
Ključne riječi
Hrčak ID:
331838
URI
Datum izdavanja:
31.8.2023.
Posjeta: 369 *