Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2025.22

Evaluation of the macrophage migration inhibitory factor (MIF) -173 G/C variant in bipolar disorder

Hasan Mervan Aytac ; Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Türkiye ; Department of Psychiatry, Basaksehir Cam and Sakura City Hospital, University of Health Sciences, Istanbul, Türkiye
Menekse Sila Yazar ; Department of Psychiatry, Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Türkiye
Yasemin Oyaci ; Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Türkiye; Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Türkiye
Sacide Pehlivan ; Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Türkiye; Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Türkiye

Sažetak

Background: This study aimed to study the genetic variant in the MIF −173 G/C in bipolar disorder (BD) by comparing genotype
distributions of the MIF −173 G/C variant between patients and healthy controls, considering clinical parameters.
Subjects and Methods: A total of 104 patients with BD and 100 healthy volunteers were included in the study. The participants
were assessed using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and sociodemographic and clinical data
forms. The Young Mania Rating Scale (YMRS), the Hamilton Depression Rating Scale (HAM-D), and The Clinical Global Impression
Scale (CGI) were administered to patients with BD. Blood samples were collected from participants to isolate their deoxyribonucleic
acid material (DNA). The MIF −173 G/C variant was determined using polymerase chain reaction (PCR) and restriction fragment
length polymorphism (RFLP) analysis.
Results: The genotype distribution (GG, GC, CC) and allele frequencies (G, C) in the BD group significantly differed from those
in the control group. The percentages of the GG genotype (p=.040) and G allele (p=.049) were significantly higher in the BD group
compared to the control group. When comparing scale scores and clinical parameters (number of manic episodes, depressive episodes,
total episodes, duration of disease, age of onset, and number of hospitalizations) based on MIF genotype distributions in patients with
BD, the CGI-I score was significantly higher in the group with the GG genotype compared to the GC/CC group (p = .029).
Conclusion: The MIF −173 G/C variant might be associated with BD and treatment response. Additionally, possessing the GG
genotype and G allele appears to be disadvantageous in terms of BD diagnosis and treatment resistance in the Turkish population.

Ključne riječi

Bipolar disorder; treatment response; macrophage migration inhibitory factor; MIF; single-nucleotide polymorphism

Hrčak ID:

332216

URI

https://hrcak.srce.hr/332216

Datum izdavanja:

29.5.2025.

Posjeta: 359 *