Izvorni znanstveni članak

https://doi.org/10.20471/acc.2024.63.03-04.06

Distribution of Respiratory Viruses in Children Admitted to Pediatric Intensive Care Unit

Gokhan Ceylan ; Department of Pediatric Intensive Care Unit, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey *
Ozlem Sandal ; Department of Pediatric Intensive Care Unit, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey
Ferhat Sari ; Department of Pediatric Intensive Care Unit, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey
Rana Isguder ; Department of Pediatric Intensive Care Unit, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey
Ahu Kara ; Department of Pediatric Infectious Diseases Unit, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey
Gamze Gülfidan ; Department of Infectious Diseases and Clinical Microbiology, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey
Yuce Ayhan ; Department of Infectious Diseases and Clinical Microbiology, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey
Ilker Devrim ; Department of Pediatric Infectious Diseases Unit, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey
Hasan Ağın ; Department of Pediatric Intensive Care Unit, Dr. Behçet Uz Children’s Hospital, Izmir, Turkey

* Dopisni autor.

Sažetak

Acute lower respiratory tract infection (LRTI) is common in children and associated
with high morbidity and mortality. The aim of this study was to determine the distribution of respiratory
viruses leading to admission of a child with the diagnosis of LRTI to pediatric intensive care
unit (PICU). The distribution of viral pathogens was determined using viral multiplex polymerase
chain reaction (PCR) in children with LRTI admitted to PICU at a tertiary-level reference pediatric
hospital. The LRTI patients without a positive viral multiplex PCR finding were excluded from the
study. Most patients were under 2 years of age (78.3%), and the most common viral pathogen resulting
in PICU admission due to viral LRTI was RSV A/B (32.8%). Thirty three patients had an underlying
disease. Ten (16.6%) patients required invasive mechanical ventilation (IMV), 37 (61.6%) required
high-flow oxygen therapy (HFOT), and two patients (3.3%) progressed to pediatric acute respiratory
distress syndrome (PARDS). Underlying chronic disease presence was the highest in the IMV group
with 90%, which decreased to 54% and 30.7% in the HFOT and standard oxygen treatment groups,
respectively (p=0.018). The patients with IMV requirements had significantly longer hospital stay
(median 8 days, range 6-13 days) compared to HFOT group (median 6 days, range 4-7.5 days] and
regular oxygen treatment group (median 3 days, range 2-3.5 days) (p<0.001). The use of multiplex
PCR for respiratory viruses may help in discriminating etiologic viral agents in patients admitted to
PICU and estimating possible complications associated with viral-specific disease. The presence of an
underlying disease in a patient with viral LRTI affects the treatment level, and treatment level affects
the duration of PICU stay.

Ključne riječi

Viral infection; Pediatric intensive care unit; Multiplex PCR; Mechanical ventilation; High-flow oxygen therapy

Hrčak ID:

333038

URI

https://hrcak.srce.hr/333038

Datum izdavanja:

31.12.2024.

Podaci na drugim jezicima: hrvatski

Posjeta: 785 *