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https://doi.org/10.20471/acc.2024.63.03-04.12
Correlation of TPO Antibody Concentration with Thyroid Hormones as a Predictor of Clinical Hypothyroidism
Mila Vasilj-Mihaljević
; Health Center Vukovar, Vukovar, Croatia; Department of Internal Medicine, Family Medicine, and History of Medicine, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
Ivan Mihaljević
; Clinical Institute of Nuclear Medicine and Radiation Protection, University Hospital Center Osijek, Croatia; Department of Mineral Research, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia Croatian Academy of Medical Sciences, Zagreb, Croatia
Sanja Bekić
; Department of Internal Medicine, Family Medicine, and History of Medicine, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Family Medicine Practice, Croatia
Željko Zubčić
; Department of Otorhinolaryngology and Maxillofacial Surgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Center Osijek, Croatia
Ana Vasilj
orcid.org/0009-0005-5742-0094
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
Danijela Daus-Šebeđak
; Family Medicine Practice, Podvinje, Croatia
Ivana Škrlec
orcid.org/0000-0003-1842-930X
; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Croatia
*
Jasminka Talapko
orcid.org/0000-0001-5957-0807
; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Croatia
* Dopisni autor.
Sažetak
This study aimed to determine the relationship between the concentration of thyroid
peroxidase antibodies (TPO-Ab) and thyroid-stimulating hormone (TSH), free thyroxine (FT4), and
free triiodothyronine (FT3) in patients with chronic lymphocytic thyroiditis. This cross-sectional study
included 144 patients diagnosed with chronic lymphocytic thyroiditis whose mean age was 46±15 years
at the time of diagnosis. According to their TSH concentration, the patients were either euthyroid or
hypothyroid. After 59 patients were excluded due to TSH levels below the reference range, no TPO-Ab
findings, substitution therapy, immune hyperthyroidism, or TPO-Ab and TSH levels outside the resolution
limits of the laboratory tests, 85 patients remained in the study. A positive correlation was found
between TPO-Ab and TSH concentration within the euthyroid and hypothyroid range and a negative
correlation between TPO-Ab and FT4 concentration. The result suggests that the TSH and TPO-Ab
concentration could be used to identify individuals at risk for the development of hypothyroidism in the
general population.
Ključne riječi
Free thyroxine (FT4); Free triiodothyronine (FT3); Hypothyroidism; Thyroglobulin; Thyroid peroxidase antibodies (TPO-Ab); Thyroid-stimulating hormone (TSH)
Hrčak ID:
333235
URI
Datum izdavanja:
31.12.2024.
Posjeta: 1.734 *