Izvorni znanstveni članak
https://doi.org/10.20471/acc.2024.63.03-04.16
Differences in Clinical Characteristics of Patients with Chronic Obstructive Pulmonary Disease (COPD) in Osijek and Zadar and Possible Association with Global DNA Methylation as an Epigenetic Biomarker
Eugenia Basioli Kasap
orcid.org/0009-0006-1095-0634
; Department of Internal Medicine, Zadar General Hospital, Zadar, Croatia
Ljubica Glavaš Obrovac
; Faculty of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia
Marijana Jukić
; Faculty of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia
Ivica Mihaljević
; Faculty of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia; Osijek University Hospital Center, Osijek, Croatia
Ana Posavi
; Osijek University Hospital Center, Osijek, Croatia
Sanda Škrinjarić Cincar
orcid.org/0000-0003-2353-0656
; Faculty of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia; Osijek Health Center, Osijek, Croatia
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* Dopisni autor.
Sažetak
Environmental factors play an important role in the onset and development of
chronic obstructive pulmonary disease (COPD). Previous studies have shown that global DNA methylation
could be a useful biomarker in COPD. We hypothesized that COPD patients from two different
Croatian regions might have clinical characteristics, quality of life, and global DNA methylation, which
could be used as a possible epigenetic marker. The study included 136 COPD patients with an average
age of 70 years, of whom about 70% were men. Among them, 37% were active smokers, 58% ex-smokers,
and 5% non-smokers. There were 69 patients in Osijek and 67 in Zadar. The control group consisted of
64 subjects who were not diagnosed with COPD or other respiratory diseases, 32 from each center. We
analyzed risk factors, severity and type of symptoms, exacerbations, comorbidities, and numerous parameters
of lung function, phenotypic characteristics, quality of life, and global DNA methylation. We found
that COPD patients in Zadar had more pronounced emphysema (P<0.001), while COPD patients from
Osijek had more severe symptoms of cough and expectoration (P<0.001 for both ). Patients from Osijek
had more cardiovascular comorbidities (P<0.001) and depression (P=0.01) than patients from Zadar.
Analysis of global DNA methylation found that patients with COPD had lower values than the control
group, but the difference was not statistically significant.
Ključne riječi
Epigenetics; Global DNA methylation; COPD; Quality of life; Lifestyle
Hrčak ID:
333249
URI
Datum izdavanja:
31.12.2024.
Posjeta: 739 *