Izvorni znanstveni članak
https://doi.org/10.20471/acc.2024.63.03-04.35
Subclinical Hypothyroidism Prevalence and Selenium Levels in Women of North Khorasan, Iran: a Cross-Sectional Study
Kimiya Hadavi
; Student Research Committee, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
Ali Esmaeili
; Department of Surgery, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
Zeynab Moallemi
; Student Research Committee, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
Javad Hashemi
; Department of Pathobiology and Laboratory Sciences, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
*
* Dopisni autor.
Sažetak
Individuals with subclinical hypothyroidism have an increased risk of developing
clinical hypothyroidism. The thyroid gland, which has the highest concentration of selenium per gram
of tissue among adults, plays a crucial role in the metabolism of thyroid hormones. This study aimed to
investigate the prevalence of subclinical hypothyroidism in the North Khorasan province of Iran and
assess the serum selenium levels in affected individuals. We conducted a prospective study involving 550
females aged 20-55. Serum samples were collected from individuals based on the study’s inclusion and
exclusion criteria. We measured the serum levels of thyroid-stimulating hormone (TSH), thyroxine (T4),
and triiodothyronine (T3). Subsequently, individuals with high TSH but normal T4 and T3 levels were
selected for further analysis (group I). The serum levels of TSH, T4, T3 (using the ELISA method), and
selenium (using the atomic absorption method) were measured and compared with those of a control
group comprising healthy women matched to group I in terms of number, age, and body mass index. The
overall prevalence of subclinical hypothyroidism in the study population was 6.48%. Significant differences
were observed in serum TSH and selenium levels between the subclinical hypothyroidism group
and the control group. Furthermore, a positive correlation between TSH and selenium levels was found
exclusively within the subclinical hypothyroidism group. The occurrence of subclinical hypothyroidism
was positively correlated with serum selenium levels.
Ključne riječi
Selenium; Thyroid hormones; Subclinical hypothyroidism
Hrčak ID:
333337
URI
Datum izdavanja:
31.12.2024.
Posjeta: 726 *