Izvorni znanstveni članak
https://doi.org/10.20471/acc.2024.63.03-04.36
Superficial Vessel Density, Retinal Nerve Fiber Layer Thickness, and Visual Field Loss in Primary Open-Angle and Pseudoexfoliative Glaucoma
Ante Prpić
orcid.org/0000-0002-0662-9198
; Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
*
Iva Ferček
; Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Kim Kasa
; Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Armin Kasumović
; Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ines Matoc
; Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Idoia Goñi Guarro
; Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Vedrana Vukić
; Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Katia Novak-Lauš
; Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ivan Sabol
orcid.org/0000-0002-5753-8528
; Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Zoran Vatavuk
; Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
* Dopisni autor.
Sažetak
The aim was to examine peripapillary and macular superficial vessel density, peripapillary
thickness of the nerve fiber layer, and inner thickness of the macula in eyes with primary
open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG) depending on the visual field
impairment. A total of 50 eyes were diagnosed as POAG and 50 as PXG. Both groups were divided
into 3 subgroups according to HAP2 criteria of visual field impairment. All eyes underwent optical coherence
tomography angiography (OCT-A). Radial peripapillary capillary (RPC) density, peripapillary
retinal nerve fiber layer (pRNFL) thickness, superficial macular vessel density (SMVD), and macular
thickness between the inner limiting membrane and inner plexiform layer (ILM-IPL) were compared.
The overall mean measured values did not show a statistically significant difference between the groups.
All measured parameters were statistically significantly lower with more extensive visual field damage
within the group. The strongest positive correlation was found between the pRNFL thickness and RPC
density values (p=0.893), and strongest negative correlation between the mean defect of visual field and
ILM-IPL (p=-0.824). No statistically significant difference was found between POAG and PXG in all
values measured on OCT-A. In conclusion, visual field loss is more strongly correlated with the loss of
nerve fiber layer thickness than the superficial vessel density, which may suggest that the loss of RNFL
precedes the loss of superficial vessel density.
Ključne riječi
Superficial vessel density; Retinal nerve fiber layer; Visual field; Optical coherence tomography angiography; Primary open angle glaucoma; Pseudoexfoliative glaucoma
Hrčak ID:
333339
URI
Datum izdavanja:
31.12.2024.
Posjeta: 544 *