Izvorni znanstveni članak
https://doi.org/10.20471/acc.2024.63.03-04.37
Prognostic Value of Tumor Budding in Sporadic Colorectal Cancer Stage II Patients with a Low Number of Lymph Nodes Examined
Josip Baković
; Dubrava University Hospital, Department of Surgery, Zagreb, Croatia
*
Čedna Tomasović-Lončarić
; ubrava University Hospital, Department of Pathology and Cytology, Zagreb, Croatia
Arijana Pačić
; ubrava University Hospital, Department of Pathology and Cytology, Zagreb, Croatia
Iva Škifić
; ubrava University Hospital, Department of Pathology and Cytology, Zagreb, Croatia
Valentin Lisek
; Dubrava University Hospital, Department of Surgery, Zagreb, Croatia
Karolina Krstanac
; ubrava University Hospital, Department of Pathology and Cytology, Zagreb, Croatia
Petra Čičak
; Department of Emergency Medicine of the City of Zagreb, Zagreb, Croatia
Paško Konjevoda
; Laboratory of Epigenomics, Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
* Dopisni autor.
Sažetak
Stage II colorectal cancer (CRC) is a major therapeutic challenge because it is not
easy to decide whether patients will benefit from adjuvant chemotherapy or not. This study was designed
as a retrospective prognostic study combining standard histopathologic parameters with tumor budding
and microsatellite instability. The study included 89 patients on elective treatment for stage II primary
colorectal adenocarcinoma from January 2011 to December 2015. Study results indicated that the
prognosis of patients with stage II CRC depended on the combination of three factors, (in the order of
importance): number of lymph nodes examined; total number of buds per 0.785 mm2 (≥5.5); and positive
lymphovascular invasion. There is increasing evidence that tumor biology and non-anatomic characteristics
are important in the prognosis and treatment of CRC. One of them is tumor budding which
is not yet an integral part of the AJCC staging system. A low number of the lymph nodes examined is
associated with high-risk patients. All patients without an adequate number of lymph nodes examined
(less than 8 lymph nodes) should a priori be considered a very high-risk group, with a very low survival
rate, and chemotherapy should be used.
Ključne riječi
Colorectal cancer; Stage II; Tumor budding; Lymph nodes; Prognosis
Hrčak ID:
333341
URI
Datum izdavanja:
31.12.2024.
Posjeta: 797 *