Recenzija, prikaz
https://doi.org/10.20471/acc.2024.63.03-04.48
Acute Generalized Exanthematous Pustulosis (AGEP) Caused by Antibiotic Polytherapy: a Case Report
Siniša Jolić
; Department of Dermatology and Venereology, Kikinda General Hospital, Kikinda, Serbia
Zdenka Šitum Čeprnja
orcid.org/0009-0003-3009-9566
; Department of Dermatology and Venereology, Split University Hospital Center, Split, Croatia
*
Toni Čeprnja
; Department of Pathology, Split University Hospital Center, Split, Croatia
Ognjen Jolić
; Department of Chemical Engineering, Faculty of Technology, University of Novi Sad, Novi Sad, Serbia
Mirna Šitum
; Department of Dermatology and Venereology, Sestre milosrdnice University Hospital Center; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
* Dopisni autor.
Sažetak
Acute generalized exanthematous pustulosis (AGEP) is a rare disease, usually associated
with drug intake or infections. It is characterized by generalized acute pustules and non-follicular
exanthema together with systemic symptoms. Histologically, it is characterized by a subcorneal
intraepidermal spongiform pustule, papillary edema and dermal vasodilatation surrounded by a polymorphous
infiltrate of neutrophils, eosinophils and mononuclear cells. The aim of this article is to
present current knowledge regarding the etiology and treatment, as well as the clinical and histologic
features of AGEP. We present a case of a 50-year-old male patient who was prescribed several antibiotics
and developed a drug-related cutaneous adverse effect. Treatment involved rapid identification
of the causative agent and its discontinuation together with supportive measures, with resolution of
symptoms within two weeks. Early diagnosis and timely treatment result in a favorable outcome and
prevent systemic complications.
Ključne riječi
Acute generalized exanthematous pustulosis; Severe cutaneous adverse reactions, drugs; Antibiotics
Hrčak ID:
333372
URI
Datum izdavanja:
31.12.2024.
Posjeta: 966 *