Izvorni znanstveni članak
https://doi.org/10.21857/m8vqrt3gp9
Hypertriglyceridemia: From an Innocent Bystander to an Independent Cardiovascular Risk Factor in Young Prehypertensive Subjects
Josipa Josipović
orcid.org/0000-0001-5545-6484
; Department of Internal Medicine, Sestre milosrdnice UHC, Zagreb, Croatia
*
Ana Jelaković
; Department of Nephrology, Hypertension, Dialysis and Transplantation, UHC, Zagreb, Croatia
Bernardica Valent Morić
; Department of Pediatrics, Sestre milosrdnice UHC, Zagreb, Croatia
Vladimir Prelević
; Clinic for Nephrology, Clinical Center of Montenegro, Podgorica, Montenegro
Gorana Mirošević
; Department of Internal Medicine, Sestre milosrdnice UHC, Zagreb, Croatia
Nikola Bulj
; Department of Cardiology and Angiology, Sestre milosrdnice UHC, Zagreb, Croatia
Ivan Pećin
; Division of metabolic diseases, Dept of internal medicine, University hospital center Zagreb
Hana Matijaca
; Department of Internal Medicine, Sestre milosrdnice UHC, Zagreb, Croatia
Iva Ivanko
; Department of Internal Medicine, Sestre milosrdnice UHC, Zagreb, Croatia
Ivo Darko Gabrić
; Department of Cardiology and Angiology, Sestre milosrdnice UHC, Zagreb, Croatia
Željko Reiner
; Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Bojan Jelaković
; Department of Nephrology, Hypertension, Dialysis and Transplantation, UHC, Zagreb, Croatia
* Dopisni autor.
Sažetak
Introduction: Prehypertension is increasingly recognized as a state associated with adverse cardiometabolic profiles, even in apparently healthy individuals. Although triglycerides (TG) have been implicated in cardiovascular disease (CVD), their role in low-risk prehypertensive populations remains underexplored.
Aim: To compare the cardiorenometabolic characteristics and cardiovascular risk (CVR) of prehypertensive (PHT) individuals with normotensive (NT) and hypertensive (HT) counterparts, with a focus on the independent contribution of TG.
Materials and Methods: A cross-sectional study included 323 untreated adults aged 18–45. Participants underwent anthropometric assessments, standardized blood pressure measurements, fasting blood sampling, spot urine collection, and transthoracic echocardiography. CVR was estimated using the Framingham 10-Year General Cardiovascular Risk Score.
Results: Compared to the NT group, PHT individuals had significantly higher BMI, waist circumference, HOMA-IR, LDL-cholesterol, TG, uric acid, and left ventricular mass index (LVMI) (p<0.05). No differences were observed in renal function markers. A stepwise increase in CVR across BP categories was evident (7.9% NT vs. 24.6% PHT vs. 48.1% HT; p<0.05). Multivariate logistic regression identified TG as an independent predictor of CVR in the PHT group (Exp(β)=1.88, 95% CI
1.08–3.28, p=0.03).
Conclusion: Hypertriglyceridemia is an early and independent marker of cardiovascular risk in young, prehypertensive individuals. Early identification may improve risk stratification and guide preventive strategies.
Ključne riječi
Prehypertension; Blood Pressure; Hypertension; Hypertriglyceridemia; Risk Factors
Hrčak ID:
333433
URI
Datum izdavanja:
25.6.2025.
Posjeta: 658 *