Review article
https://doi.org/10.64266/amu.1.1.10
Vasopressors in Trauma Patients: A Review of Indications, Benefits, and Controversies
Višnja Nesek Adam
orcid.org/0000-0002-6521-4136
; University Hospital Sveti Duh, Zagreb, Croatia
*
Adis Keranović
; University Hospital Centre Zagreb, Zagreb, Croatia
Anđela Simić
; Institute of Emergency Medicine of Varaždin County, Varaždin, Croatia
Martina Matolić
; University Hospital Sveti Duh, Zagreb, Croatia
Tamara Murselović
; University Hospital Sveti Duh, Zagreb, Croatia
* Corresponding author.
Abstract
Trauma-induced shock, primarily classified as hypovolemic shock, is a critical condition resulting from significant blood loss or fluid shifts, leading to impaired tissue perfusion and oxygenation. The physiological response to this state involves a two-phase process: an initial activation of the sympathetic nervous system (SNS) to maintain perfusion of vital organs, followed by a later phase characterized by receptor downregulation, metabolic acidosis, and the development of multi-organ dysfunction. The use of vasopressors in trauma-induced shock, particularly norepinephrine, is a common approach to managing hypotension. However, their application remains a subject of ongoing debate due to concerns about their potential impact on microcirculatory flow, tissue perfusion, and endothelial function. The choice of vasopressor, optimal dosing, and timing of initiation are contentious issues, as these factors significantly influence patient outcomes. Further research is essential to refine treatment algorithms and improve the prognosis of critically ill trauma patients.
Keywords
Multi-Organ Dysfunction; Shock; Trauma; Vasopressors
Hrčak ID:
333868
URI
Publication date:
1.2.2025.
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