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Blood Biomarkers of Alcohol Abuse

Marjan Bilban
Sonja Vrhovec
Majda Zorec Karlovšek

Puni tekst: engleski, pdf (273 KB) str. 253-259 preuzimanja: 4.883* citiraj
APA 6th Edition
Bilban, M., Vrhovec, S. i Zorec Karlovšek, M. (2003). Blood Biomarkers of Alcohol Abuse. Arhiv za higijenu rada i toksikologiju, 54 (4), 253-259. Preuzeto s
MLA 8th Edition
Bilban, Marjan, et al. "Blood Biomarkers of Alcohol Abuse." Arhiv za higijenu rada i toksikologiju, vol. 54, br. 4, 2003, str. 253-259. Citirano 08.12.2021.
Chicago 17th Edition
Bilban, Marjan, Sonja Vrhovec i Majda Zorec Karlovšek. "Blood Biomarkers of Alcohol Abuse." Arhiv za higijenu rada i toksikologiju 54, br. 4 (2003): 253-259.
Bilban, M., Vrhovec, S., i Zorec Karlovšek, M. (2003). 'Blood Biomarkers of Alcohol Abuse', Arhiv za higijenu rada i toksikologiju, 54(4), str. 253-259. Preuzeto s: (Datum pristupa: 08.12.2021.)
Bilban M, Vrhovec S, Zorec Karlovšek M. Blood Biomarkers of Alcohol Abuse. Arh Hig Rada Toksikol. [Internet]. 2003 [pristupljeno 08.12.2021.];54(4):253-259. Dostupno na:
M. Bilban, S. Vrhovec i M. Zorec Karlovšek, "Blood Biomarkers of Alcohol Abuse", Arhiv za higijenu rada i toksikologiju, vol.54, br. 4, str. 253-259, 2003. [Online]. Dostupno na: [Citirano: 08.12.2021.]

The biological, clinical and social effects of alcohol abuse call for objective and specific biomarkers of alcohol-related diseases and early detection of alcohol consumers at risk. Alcohol abusers may exhibit several clinical and/or chemical changes. Changes in parameters such as gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and mean corpuscular volume (MCV) may serve as biomarkers of chronic alcoholism. All available biomarkers have two drawbacks. The first is that they indicate adverse effects in a particular organ, but tell little about their aetiology. The second is that they are not sensitive enough to detect abuse before it results in organic impairment. The 1990s have seen the introduction of a new diagnostic biomarker, carbohydrate-deficient transferrin (CDT). Reduced concentrations of this biomarker are found in serum after regular high alcohol intake. Relying on literature and their own clinical experience, the authors conclude that CDT seems to meet the clinical criteria of reliability and specificity.

Ključne riječi
alanine amino transferase; aspartate amino transferase; carbohydrate-deficient transferrin; gamma-glutamyl transpeptidase; liver enzymes; mean corpuscular volume

Hrčak ID: 342



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