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Reversible »Brain Atrophy« in Patients with Cushing’s Disease

Živko Gnjidić
Tomislav Sajko
Nenad Kudelić
Maša Malenica
Branka Vizner
Milan Vrkljan
Josip Hat
Zoran Rumboldt

Puni tekst: engleski, pdf (166 KB) str. 1165-1170 preuzimanja: 277* citiraj
APA 6th Edition
Gnjidić, Ž., Sajko, T., Kudelić, N., Malenica, M., Vizner, B., Vrkljan, M., ... Rumboldt, Z. (2008). Reversible »Brain Atrophy« in Patients with Cushing’s Disease. Collegium antropologicum, 32 (4), 1165-1170. Preuzeto s https://hrcak.srce.hr/34303
MLA 8th Edition
Gnjidić, Živko, et al. "Reversible »Brain Atrophy« in Patients with Cushing’s Disease." Collegium antropologicum, vol. 32, br. 4, 2008, str. 1165-1170. https://hrcak.srce.hr/34303. Citirano 14.12.2019.
Chicago 17th Edition
Gnjidić, Živko, Tomislav Sajko, Nenad Kudelić, Maša Malenica, Branka Vizner, Milan Vrkljan, Josip Hat i Zoran Rumboldt. "Reversible »Brain Atrophy« in Patients with Cushing’s Disease." Collegium antropologicum 32, br. 4 (2008): 1165-1170. https://hrcak.srce.hr/34303
Harvard
Gnjidić, Ž., et al. (2008). 'Reversible »Brain Atrophy« in Patients with Cushing’s Disease', Collegium antropologicum, 32(4), str. 1165-1170. Preuzeto s: https://hrcak.srce.hr/34303 (Datum pristupa: 14.12.2019.)
Vancouver
Gnjidić Ž, Sajko T, Kudelić N, Malenica M, Vizner B, Vrkljan M i sur. Reversible »Brain Atrophy« in Patients with Cushing’s Disease. Collegium antropologicum [Internet]. 2008 [pristupljeno 14.12.2019.];32(4):1165-1170. Dostupno na: https://hrcak.srce.hr/34303
IEEE
Ž. Gnjidić, et al., "Reversible »Brain Atrophy« in Patients with Cushing’s Disease", Collegium antropologicum, vol.32, br. 4, str. 1165-1170, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/34303. [Citirano: 14.12.2019.]

Sažetak
During the past 25 years, we came across 60 patients with corticotroph pituitary adenomas and Cushing’s disease.
Neuroradiological examination showed prominent volume loss of the brain parenchyma, unexpected for the patient’s
age. This »brain atrophy« appeared to regress after surgical removal of pituitary adenoma and normalization of cortisol
level. Observed difference between degree of »brain atrophy« in the Cushing’s disease group and in the control group was
statistically significant (p<0.001). The degree of »brain atrophy« correlated well with the duration of Cushing’s disease.
Partial reversibility of »brain atrophy« was noticed during the 2nd, 3rd and 4th year after surgery and normalization of
cortisol level. Increased cortisol level is one of the causative factors in pathogenesis of »brain atrophy«. Loss of brain volume
is at least partially reversible after normalization of cortisol levels.

Ključne riječi
Cushing’s disease; brain atrophy; pituitary ACTH adenoma; hypercortisolism; transsphenoidal surgery; CT; MRI; reversibility

Hrčak ID: 34303

URI
https://hrcak.srce.hr/34303

Posjeta: 472 *