Izvorni znanstveni članak
Influence of Insolation on Osteoporosis Progression in Androgen Deprived Nonmetastatic Prostate Cancer Patients
Josip Španjol
Antun Maričić
Maksim Valenčić
Romano Oguić
Kristijan Krpina
Alen Protić
Aldo Ivančić
Mirna Bobinac
Dora Fučkar
Božidar Vojnikov
Sažetak
Prostate cancer is a major public health problem in all the developed countries. Increasing numbers of men with
nonmetastatic prostate cancer are receiving long-term androgen deprivation therapy (ADT). ADT is associated the loss of
bone mineral density and a increased risk of bone fractures. The standard recommendations for male bone health include
above all optimizing calcium and vitamin D intake, and exercise. Vitamin D3 is an essential factor in the maintenance
of bone health and calcium homeostasis. The main supply of vitamin D3 is obtained through photosynthesis in the
skin. The aim of this study was to investigate the influence of insolation on osteoporosis progression in androgen deprived
nonmetastatic prostate cancer patients. We divided our androgen deprived prostate cancer patients in 2 groups.
The first group (A) consists of 224 patients with insolation rate less then 3h per week. The second group (B) consists of
174 patients with insolation rate greater then 10h per week. With a questionnaire we determined, that patients from both
groups were 70 to 80 years old, body mass index was 25–30 kg/m2, androgen deprivation was 4–6 years and received no
vitamin D supplements. In the group A 21.86% suffered pathologic fractures do to osteoporosis. In the group B 10.92%
patients suffered from osteoporotic bone fractures. The risk for pathological bone fractures is significantly greater in the
group A. In conclusion higher insolation in androgen deprived nonmetastatic prostate cancer patients significantly decreases
the osteoporosis progression and the risk of pathologic bone fractures.
Ključne riječi
androgen deprivation; insolation; male osteoporosis; pathologic bone fractures; vitamin D
Hrčak ID:
34545
URI
Datum izdavanja:
1.10.2008.
Posjeta: 1.223 *