Izvorni znanstveni članak
Expression of Bone Morphogenetic Proteins, Cartilage-Derived Morphogenetic Proteins and Related Receptors in Normal and Osteoarthritic Human Articular Cartilage
Dragica Bobinac
Josip Španjol
Marin Marinović
Sanja Zoričić Cvek
Ivana Marić
Tedi Cicvarić
Dora Fučkar
Dean Markić
Božidar Vojniković
Sažetak
Newborn and adult articular cartilage expresses bone (BMPs) and cartilage derived morphogenetic proteins (CDMPs).
These morphogenetic proteins act over membrane receptors (BMPRs). We examined the expression pattern of BMP-7,
BMP-3, CDMP-1, CDMP-2 and their receptors in adult normal and osteoarthritic, articular, knee cartilage. Immunostaining
was carried out using polyclonal antibodies. The expression of BMP-7,-3, CDMP-1,-2 was detected in all layers
of normal articular cartilage with the strongest expression in chondrocytes of the transitional layer. BMP-7 and CDMPs
expression decreased in osteoarthritic articular cartilage whereas BMP-3 expression was absent. BMPR-IA and BMPR-II
were strongly expressed in both normal and osteoarthritic articular cartilage. BMPR-IB was not expressed in osteoarthritic
(OA) cartilage. BMPs and CDMPs with intact signalling play an important role in articular cartilage homeostasis,
preventing cartilage degeneration.
Ključne riječi
articular cartilage; bone morphogenetic proteins; cartilage derived morphogenetic proteins; osteoarthritis
Hrčak ID:
34546
URI
Datum izdavanja:
1.10.2008.
Posjeta: 1.187 *