Izvorni znanstveni članak
Predictive Value of Preoperative Positron Emission Tomography/Computed Tomography (PET/CT) in Staging of Patients with High-Risk Melanoma
Sunčana Divošević
Nika Filipović
orcid.org/0000-0001-8229-9373
; Department of Dermatology and Venereology, University Hospital Centre Sestre milosrdnice, Zagreb, Croatia
*
Leo Košuta
; School of Medicine, University of Zagreb, Croatia
Mirna Šitum
; Department of Dermatology and Venereology, University Hospital Centre Sestre milosrdnice, Zagreb, Croatia
Marija Buljan
; Department of Dermatology and Venereology, University Hospital Centre Sestre milosrdnice, Zagreb, Croatia
* Dopisni autor.
Sažetak
Accurate staging of high-risk melanoma patients is imperative to ensure
effective and appropriate therapy but also to estimate the potential risk of recurrence.
Despite numerous studies previously conducted, no consensus has been reached on
the optimal posttreatment follow-up method for high-risk melanoma patients. There
are no clear indications for PET/CT in follow-up or initial staging of clinically asymptomatic
high-risk melanoma patients. The aim of our study was to determine the predictive
value of preoperative PET/CT in staging of such patients and its implication on further
therapeutic decisions.
A retrospective cohort study of 85 patients with T3 and T4 melanoma without clinical
signs of nodal involvement or distant metastases was conducted. Patients underwent
PET/CT as a part of preoperative staging and results were compared with SLNB.
In this study combined sensitivity and specificity of PET/CT for identifying regional and
metastatic disease were 54% and 98%, respectively. The positive predictive value (PPV)
of PET/CT was 95% while negative predictive value (NPV) was 71%. Preoperative PET/CT
changed the treatment plan for 26 patients (31%)
Our study showed that PET/CT certainly has a role in the preoperative staging of highrisk
melanoma patients, but it also requires a mandatory sentinel lymph node biopsy
afterwards
Ključne riječi
melanoma; PET/CT, high risk; preoperative; staging
Hrčak ID:
346958
URI
Datum izdavanja:
22.6.2025.
Posjeta: 0 *