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Acta Pharmaceutica, Vol. 59 No. 3, 2009.

Kratko priopćenje
https://doi.org/10.2478/v10007-009-0023-x

Development and physicochemical evaluation of pharmacosomes of diclofenac

AJAY SEMALTY   ORCID icon orcid.org/0000-0002-2512-8516 ; Department of Pharmaceutical Sciences, H. N. B. Garhwal University, Srinagar Garhwal, India
MONA SEMALTY ; Department of Pharmaceutical Sciences, H. N. B. Garhwal University, Srinagar Garhwal, India
DEVENDRA SINGH ; Department of Chemistry, H.N.B. Garhwal University, Srinagar Garhwal, India
M. S. M. RAWAT ; Department of Chemistry, H.N.B. Garhwal University, Srinagar Garhwal, India

Puni tekst: engleski, pdf (124 KB) str. 335-344 preuzimanja: 2.067* citiraj
APA 6th Edition
SEMALTY, A., SEMALTY, M., SINGH, D. i RAWAT, M.S.M. (2009). Development and physicochemical evaluation of pharmacosomes of diclofenac. Acta Pharmaceutica, 59 (3), 335-344. https://doi.org/10.2478/v10007-009-0023-x
MLA 8th Edition
SEMALTY, AJAY, et al. "Development and physicochemical evaluation of pharmacosomes of diclofenac." Acta Pharmaceutica, vol. 59, br. 3, 2009, str. 335-344. https://doi.org/10.2478/v10007-009-0023-x. Citirano 27.03.2019.
Chicago 17th Edition
SEMALTY, AJAY, MONA SEMALTY, DEVENDRA SINGH i M. S. M. RAWAT. "Development and physicochemical evaluation of pharmacosomes of diclofenac." Acta Pharmaceutica 59, br. 3 (2009): 335-344. https://doi.org/10.2478/v10007-009-0023-x
Harvard
SEMALTY, A., et al. (2009). 'Development and physicochemical evaluation of pharmacosomes of diclofenac', Acta Pharmaceutica, 59(3), str. 335-344. doi: https://doi.org/10.2478/v10007-009-0023-x
Vancouver
SEMALTY A, SEMALTY M, SINGH D, RAWAT MSM. Development and physicochemical evaluation of pharmacosomes of diclofenac. Acta Pharm. [Internet]. 2009 [pristupljeno 27.03.2019.];59(3):335-344. doi: https://doi.org/10.2478/v10007-009-0023-x
IEEE
A. SEMALTY, M. SEMALTY, D. SINGH i M.S.M. RAWAT, "Development and physicochemical evaluation of pharmacosomes of diclofenac", Acta Pharmaceutica, vol.59, br. 3, str. 335-344, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0023-x

Sažetak
Pharmacosomes are amphiphilic lipid vesicular systems that have shown their potential in improving the bioavailability of poorly water soluble as well as poorly lipophilic drugs. Diclofenac is a poorly water soluble drug and also causes gastrointestinal toxicity. To improve the water solublity of diclofenac, its pharmacosomes (phospholipid complex) have been prepared and evaluated for physicochemical analysis. Diclofenac was complexed with phosphatidylcholine (80 %) in equimolar ratio, in the presence of dichloromethane, by the conventional solvent evaporation technique. Pharmacosomes thus prepared were evaluated for drug solubility, drug content, surface morphology (by scanning electron microscopy), phase transition behaviour (by differential scanning calorimetry), crystallinity (by X-ray powder diffraction) and in vitro dissolution. Pharmacosomes of diclofenac were found to be irregular or disc shaped with rough surfaces in SEM. Drug content was found to be 96.2  1.1 %. DSC thermograms and XRPD data confirmed the formation of the phospholipid complex. Water solubility of the prepared complex was found to be 22.1 µg mL1 as compared to 10.5 µg mL1 of diclofenac. This improvement in water solubility in prepared pharmacosomes may result in improved dissolution and lower gastrointestinal toxicity. Pharmacosomes showed 87.8 % while the free diclofenac acid showed a total of only 60.4 % drug release at the end of 10 h of the dissolution study.

Ključne riječi
pharmacosome; phospholipid; complex; solubility; diclofenac

Hrčak ID: 38925

URI
https://hrcak.srce.hr/38925

[hrvatski]

Posjeta: 2.592 *