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Preoperative Clonidine or Levobupivacaine – Effect on Systemic Inflammatory Stress Response

Jasminka Peršec ; Anesthesiology, Resuscitation and Intensive Care Medicine Clinic, University Hospital »Dubrava«, Zagreb, Croatia
Zoran Peršec ; Department of Urology, University Hospital »Dubrava«, Zagreb, Croatia
Damir Buković ; Department of Gynecology and Obstetrics, University Hospital Center »Zagreb«, Zagreb, Croatia
Vlasta Merc ; Anesthesiology, Resuscitation and Intensive Care Medicine Clinic, University Hospital »Dubrava«, Zagreb, Croatia
Jasminka Pavelić ; Institute »Rudjer Bo{kovi}«, Division of Molecular Medicine, Zagreb, Croatia
Tomislav Zupić ; Department of Gynecology and Obstetrics, University Hospital Center »Zagreb«, Zagreb, Croatia


Puni tekst: engleski pdf 61 Kb

str. 573-577

preuzimanja: 317

citiraj


Sažetak

With perioperative pain control it is possible to supervise immune system, release of inflammation mediators, and influence on treatment outcome. Use of analgetics before the pain stimulus (preventive analgesia) obstruct development of neuroplastic changes in central nervous system, and reduces pain. Investigation hypothesis was that preoperative epidural clonidine is more efficient in blockade of systemic inflammatory stress response comparing to levobupivacaine. Patients were allocated to three groups, according to preoperative epidural use of clonidine, levobupivacaine or saline (control group). Before operation, 1 h after the beginning, 1 h, 6 h, 12 h and 24 h after the operation following parameters were analyzed: interleukine-6, C-reactive protein and leukocyte count. There were no significant differences between groups in age, gender, body mass index and operation time. In preoperative clonidine group, we found significant reduction in interleukine-6 levels throughout investigation time, compared to preoperative levobupivacaine group and control group. Also, C-reactive protein was significantly lower at the end of investigation, compared to other two groups. Leukocyte count was lower, and within the normal range in all investigation times only in preoperative clonidine group. We demonstrated significant difference that support importance of clonidine central effect on pain pathways and systemic inflammatory blockade.

Ključne riječi

clonidine, levobupivacaine, systemic inflammatory stress response, epidural analgesia

Hrčak ID:

40557

URI

https://hrcak.srce.hr/40557

Posjeta: 650 *