Kratko priopćenje

https://doi.org/10.2478/v10007-009-0037-4

Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407

VIKRANT VYAS ; Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra-415124, I
PANKAJKUMAR SANCHETI ; Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra-415124, I
POONAM KAREKAR ; Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra-415124, I
MANALI SHAH ; Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra-415124, I
YOGESH PORE ; Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra-415124, I

Sažetak

Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and powder XRPD studies demonstrated the presence of strong hydrogen bonding interactions, a significant decrease in crystallinity and the possibility of existence of amorphous entities of the drug. In the binary systems tested, 1:0.5 proportion of tadalafil/poloxamer 407 showed rapid dissolution of tadalafil (DE30 70.9 ± 3.6 %). In contrast, higher proportions of poloxamer 407 (1:1.5 and 1:2.5) offered no advantage towards dissolution enhancement of the drug from corresponding binary systems indicating altered rheological characteristics of the polymer, at its higher concentration, which might have retarded the release rate of tadalafil.

Ključne riječi

tadalafil; solid dispersion; poloxamer 407; dissolution

Hrčak ID:

40740

URI

https://hrcak.srce.hr/40740

Datum izdavanja:

1.12.2009.

Podaci na drugim jezicima: hrvatski

Posjeta: 5.524 *