Acta Pharmaceutica, Vol. 56 No. 4, 2006.
Izvorni znanstveni članak
Evaluation of a drug with wax like properties as a melt binder
RAVINDRA S. DHUMAL
SHAMKANT L. SHIMPI
BHASKAR CHAUHAN
KAKASAHIB R. MAHADIK
ANANT PARADKAR
Sažetak
The study investigates ibuprofen with wax-like properties as a multifunctional agent (as an active component and as a melt binder). Binding efficiency was compared with granules prepared by wet granulation using polyvinylpyrollidone (PVP K-30) as a binder for micromeritic, physical and mechanical properties such as angle of repose, particle size distribution Carr’s index, Hausner’s ratio, crushing strength, percentage fines, Heckel plot study and tensile strength. To check the binder distribution during melt granulation, content uniformity was determined. To check changes in the physical state of ibuprofen, XRPD, DSC and FTIR studies were carried out. The present study underlines the fact that ibuprofen may be adopted as a binder in ibuprofen formulations using the melt granulation technique
Ključne riječi
ibuprofen; binder; melt granulation
Hrčak ID:
4609
URI
Datum izdavanja:
1.12.2006.
Posjeta: 3.406 *