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https://doi.org/10.2478/v10007-010-0009-8

Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles

ADEL H. MANDOUR ; Chemistry Department of Natural Compounds, National Research Centre, Gizza, Egypt
ESLAM R. EL-SAWY ; Chemistry Department of Natural Compounds, National Research Centre, Gizza, Egypt
KAMEL H. SHAKER ; Organic Chemistry NWII,1/2, University of Bayreuth, Bayreuth, Germany
MOHAMED A. MUSTAFA ; Research Unit, Egypt Pharmacist Co., Cairo, Egypt

Puni tekst: engleski, pdf (102 KB) str. 73-88 preuzimanja: 742* citiraj
APA 6th Edition
MANDOUR, A.H., EL-SAWY, E.R., SHAKER, K.H. i MUSTAFA, M.A. (2010). Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles. Acta Pharmaceutica, 60 (1), 73-88. https://doi.org/10.2478/v10007-010-0009-8
MLA 8th Edition
MANDOUR, ADEL H., et al. "Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles." Acta Pharmaceutica, vol. 60, br. 1, 2010, str. 73-88. https://doi.org/10.2478/v10007-010-0009-8. Citirano 18.10.2019.
Chicago 17th Edition
MANDOUR, ADEL H., ESLAM R. EL-SAWY, KAMEL H. SHAKER i MOHAMED A. MUSTAFA. "Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles." Acta Pharmaceutica 60, br. 1 (2010): 73-88. https://doi.org/10.2478/v10007-010-0009-8
Harvard
MANDOUR, A.H., et al. (2010). 'Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles', Acta Pharmaceutica, 60(1), str. 73-88. https://doi.org/10.2478/v10007-010-0009-8
Vancouver
MANDOUR AH, EL-SAWY ER, SHAKER KH, MUSTAFA MA. Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles. Acta Pharm. [Internet]. 2010 [pristupljeno 18.10.2019.];60(1):73-88. https://doi.org/10.2478/v10007-010-0009-8
IEEE
A.H. MANDOUR, E.R. EL-SAWY, K.H. SHAKER i M.A. MUSTAFA, "Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles", Acta Pharmaceutica, vol.60, br. 1, str. 73-88, 2010. [Online]. https://doi.org/10.2478/v10007-010-0009-8

Sažetak
A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a-j, 5a-j and 6a-j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities. Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of N-alkyl indole-3-carboxaldehydes 1a-j, 2a-j and 3a-j with ten times their mass of polyphosphoric acid as a condensing agent. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anticonvulsant activities compared to indomethacin, flufenamic acid and diazepam as positive controls. Detailed synthesis, spectroscopic and toxicity data are reported.

Ključne riječi
indole-3-carboxaldehyde; anti-inflammatory activity; anticonvulsant activity; analgesic activity

Hrčak ID: 48283

URI
https://hrcak.srce.hr/48283

[hrvatski]

Posjeta: 1.119 *