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Pregledni rad

https://doi.org/10.2478/10004-1254-61-2010-1976

Thallium Toxicity in Humans

Petra Cvjetko ; Department of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Ivan Cvjetko ; University Hospital Merkur, Medical School, University of Zagreb, Zagreb, Croatia
Mirjana Pavlica ; Department of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia


Puni tekst: engleski pdf 92 Kb

str. 111-118

preuzimanja: 1.884

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Sažetak

Thallium is a naturally occurring trace element, widely distributed in the earth’s crust, but at very low concentrations. It does not have a known biological use and does not appear to be an essential element for life. It has been considered one of the most toxic heavy metals.
Occasionally, there are reports on thallium poisoning as results of suicide or murder attempt or accident. The main threat to humans is through occupational exposure, environmental contamination, and accumulation in food, mainly in vegetables grown on contaminated soil. Increasing use in emerging new technologies and demanding high-tech industry constantly raise concern about exposure risk to all living organisms. Thallium is considered a cumulative poison that can cause adverse health effects and degenerative changes in many organs. The effects are the most severe in the nervous system. The exact mechanism of thallium toxicity still remains unknown, although impaired glutathione metabolism, oxidative stress, and disruption
of potassium-regulated homeostasis may play a role. The lack of data about mutagenic, carcinogenic, or teratogenic effects of thallium compounds in humans calls for further research.

Ključne riječi

alopecia, environmental contamination, heavy metals, neuropathy, peripheral, poisoning

Hrčak ID:

49025

URI

https://hrcak.srce.hr/49025

Podaci na drugim jezicima: hrvatski

Posjeta: 4.241 *