Izvorni znanstveni članak
Cytogenetics of Multiple Myeloma
Ružica Lasan Trčić
; Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia
Ika Kardum Skelin
; Laboratory for Cytology and Hematology, Department of Medicine, University Hospital »Merkur«, Zagreb, Croatia
Dunja Šušterčić
; Laboratory for Cytology and Hematology, Department of Medicine, University Hospital »Merkur«, Zagreb, Croatia
Ana Planinc-Peraica
; Department of Medicine, University Hospital »Merkur«, Zagreb, Croatia
Radmila Ajduković
; Department of Medicine, University Hospital Dubrava, Zagreb, Croatia
Višnja Hariš
; Department of Medicine, University Hospital Dubrava, Zagreb, Croatia
Rajko Kušec
; Clinical Institute of Laboratory Diagnostics, University Hospital Dubrava, Zagreb, Croatia
Davor Begović
; Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia
Sažetak
Great studies of multiple myeloma (MM) strongly suggested that specific chromosomal changes are of prognostic significance in patients with MM1. We have performed cytogenetic analysis and recently fluorescent in situ hybridization (FISH) on 43 cases of MM. Clonal chromosomal changes were present in 24 (56%) cases. Hyperdiploid karyotype was found in 12 (50%) cases, hypodiploid in 8 (33%) cases, and 4 (17%) cases had a pseudodiploid karyotype. The most common numerical abnormalities were gains of whole chromosomes 15, 11, 3 and 6. Whole chromosome losses were also frequent involving chromosomes X, 13, 14, and 8. Most cases showed also structural rearrangements 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t(11;14)(q13;q32) (n=4, 17%). Chromosome –13/13q deletion was found in 42% (n=10) cases; complete loss of 13 was observed in 67% (n=7) cases, whereas 33% (n=3) had interstitial deletions. In the majority of the cases there was a mixture of abnormal and normal metaphases.
Ključne riječi
bone marrow; multiple myeloma; cytogenetics; DMSO
Hrčak ID:
51239
URI
Datum izdavanja:
10.3.2010.
Posjeta: 2.761 *