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Effect of Botulinum Toxin-A Injection on Intraocular Pressure and Proptosis in Thyroid Associated Orbitopathy

Mladen Lešin ; Eye Department, University Hospital Center Split, Split, Croatia
Lovro Bojić ; Eye Department, University Hospital Center Split, Split, Croatia
Rinaldo Romac ; Department of Neurology, University Hospital Center Split, Split, Croatia
Joško Leštin ; Department of Obstetrics and Gynecology, School of Medicine, University of Zagreb, Zagreb, Croatia
Milan Ivanišević ; Eye Department, University Hospital Center Split, Split, Croatia
Davor Galetović ; Eye Department, University Hospital Center Split, Split, Croatia
Veljko Rogošić ; Eye Department, University Hospital Center Split, Split, Croatia


Puni tekst: engleski pdf 52 Kb

str. 1155-1161

preuzimanja: 448

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Sažetak

The aim of this study was to evaluate the effects of extraocular muscle injection of botulinum toxin-A (BTX-A) on intraocular pressure (IOP) and proptosis in patients with ocular motility disturbances in thyroid associated orbitopathy (TAO). In 17 patients (20 eyes) with restrictive strabismus and diplopia, BTX -A injections were applied. Intraocular pressure was measured with a Goldmann applanation tonometer in primary gaze position before and 2–4 weeks after BTX-A injection. Extraorbital prominention of the eyeball was measured before and after BTX -A injection using a Hertel instrument. Before the injection, the mean IOP in primary position of gaze was 18.6± 2.8 mmHg and 2–4 weeks after BTX-A injection was 16.9±3.3 mmH; (p=0.001). There was no statistically significant difference in Hertel egzophthalmometer readings before and after BTX-A injection, 21.5±2.7 mm vs 22.0± 2.6 mm; (p=0.678). In conclusion, BTX-A injection has a secondary lowering effect on IOP in TAO due to relaxation of extraocular muscles, but with no influence on proptosis.

Ključne riječi

thyroid related orbitopathy, botulinum toxin-A, intraocular pressure, proptosis

Hrčak ID:

51483

URI

https://hrcak.srce.hr/51483

Posjeta: 785 *