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CATECHOL-O-METHYL TRANSFERASE AND SCHIZOPHRENIA

Marina Šagud   ORCID icon orcid.org/0000-0001-9620-2181 ; 1School of Medicine, University of Zagreb, Department of Psychiatry, University Hospital Centre Zagreb, Croatia
Dorotea Műck-Šeler ; Division of Molecular Medicine, Rudjer Bošković Institute, Bijenička 54, Zagreb, Croatia
Alma Mihaljević-Peleš ; 1School of Medicine, University of Zagreb, Department of Psychiatry, University Hospital Centre Zagreb, Croatia
Bjanka Vuksan-Ćusa ; 1School of Medicine, University of Zagreb, Department of Psychiatry, University Hospital Centre Zagreb, Croatia
Maja Živković ; Neuropsychiatric Hospital “Dr. Ivan Barbot”, Popovača, Croatia
Miro Jakovljević ; 1School of Medicine, University of Zagreb, Department of Psychiatry, University Hospital Centre Zagreb, Croatia
Nela Pivac ; Division of Molecular Medicine, Rudjer Bošković Institute, Bijenička 54, Zagreb, Croatia

Puni tekst: engleski, pdf (237 KB) str. 270-274 preuzimanja: 535* citiraj
APA 6th Edition
Šagud, M., Műck-Šeler, D., Mihaljević-Peleš, A., Vuksan-Ćusa, B., Živković, M., Jakovljević, M. i Pivac, N. (2010). CATECHOL-O-METHYL TRANSFERASE AND SCHIZOPHRENIA. Psychiatria Danubina, 22 (2), 270-274. Preuzeto s https://hrcak.srce.hr/55697
MLA 8th Edition
Šagud, Marina, et al. "CATECHOL-O-METHYL TRANSFERASE AND SCHIZOPHRENIA." Psychiatria Danubina, vol. 22, br. 2, 2010, str. 270-274. https://hrcak.srce.hr/55697. Citirano 04.08.2020.
Chicago 17th Edition
Šagud, Marina, Dorotea Műck-Šeler, Alma Mihaljević-Peleš, Bjanka Vuksan-Ćusa, Maja Živković, Miro Jakovljević i Nela Pivac. "CATECHOL-O-METHYL TRANSFERASE AND SCHIZOPHRENIA." Psychiatria Danubina 22, br. 2 (2010): 270-274. https://hrcak.srce.hr/55697
Harvard
Šagud, M., et al. (2010). 'CATECHOL-O-METHYL TRANSFERASE AND SCHIZOPHRENIA', Psychiatria Danubina, 22(2), str. 270-274. Preuzeto s: https://hrcak.srce.hr/55697 (Datum pristupa: 04.08.2020.)
Vancouver
Šagud M, Műck-Šeler D, Mihaljević-Peleš A, Vuksan-Ćusa B, Živković M, Jakovljević M i sur. CATECHOL-O-METHYL TRANSFERASE AND SCHIZOPHRENIA. Psychiatria Danubina [Internet]. 2010 [pristupljeno 04.08.2020.];22(2):270-274. Dostupno na: https://hrcak.srce.hr/55697
IEEE
M. Šagud, et al., "CATECHOL-O-METHYL TRANSFERASE AND SCHIZOPHRENIA", Psychiatria Danubina, vol.22, br. 2, str. 270-274, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/55697. [Citirano: 04.08.2020.]

Sažetak
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT
enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Given the association between schizophrenia and decreased dopamine activity in the prefrontal cortex, it is not surprising that Val108/158Met polymorphism is among the most extensively investigated polymorphisms in schizophrenia. According to different studies, Val allele may be a small risk factor for schizophrenia. There is also some evidence that Val108/158Met polymorphism influences the age of onset of schizophrenia, cognitive function, severity of psychotic symptoms, as well as efficacy and adverse events of antipsychotics. Heterogenity of patient population has undoubtedly influenced the results of these studies. Interaction of Val108/158Met polymorphism with other genes and environmental factors is an important avenue for future research.

Ključne riječi
COMT Val108/158Met polymorphism; schizophrenia; response to antipsychotics

Hrčak ID: 55697

URI
https://hrcak.srce.hr/55697

Posjeta: 891 *