Conference paper

PERSONALIZED ANTIPSYCHOTIC TREATMENT: THE ADVERSE EFFECTS PERSPECTIVES

Blanka Kores Plesničar ; Pychiatric Clinic Ljubljana, Ljubljana, Slovenia

Abstract

Antipsychotics are the lodestar in the treatment of schizophrenia despite the variability of the therapeutic response and druginduced
adverse effects (especially extrapyramidal symptoms, gain weight, and metabolic disturbances). More and more data are supporting the notion that genetic factors - as well as often overlooked personal and environmental factors - that define the interindividual differences in pharmacokinetic and pharmacodynamic treatment response. At present, there are no practical pharmakogenetic tests that could be used in everyday clinical practice; however, in the field of psychiatry they are expected within a few years. Pharmacogenetic tests will indubitably become an important tool for personalized prescription.

Keywords

pharmacogenetics; pharmacogenomics; pharmacokinetics; pharmacodynamics; genetic testing; personalized prescription; antipsychotics; adverse effects

Hrčak ID:

55850

URI

https://hrcak.srce.hr/55850

Publication date:

30.6.2010.

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