Izvorni znanstveni članak
Epinephrine administration via a laryngeal mask airway: what is the optimal dose?
Hung-Jung Lin
; Department of Biotechnology, Southern Tainan University of Technology, Emergency Department, Chi-Mei Medical Center, 901 Chung-Hwa Road, Yung Kang Tainan 710, Taiwan
Kuo-Tai Chen
; School of Medicine, Taipei Medical University, Emergency Department, Chi-Mei Medical Center, 901 Chung-Hwa Road, Yung Kang Tainan 710, Taiwan
Chin-Kun Liao
; Department of Emergency Medicine, Chi-Mei Medical Center, Liouying
Ning-Ping Foo
; Department of Emergency Medicine, Chi-Mei Medical Center, Liouying
Hung-Jung Lin
; Department of Biotechnology, Southern Tainan University of Technology
Chin-Chan Lin
; Department of Medical Research, Chi-Mei Medical Center
How-Ran Guo
; Department of Environmental and Occupational Health and Department of Environmental and Occupational Medicine, Medical College,National Cheng Kung University
Sažetak
Background. The aim of this animal study was to clarify the effects of laryngeal mask airway (LMA)-administrated epinephrine and to assess the optimal dose.
Methods. Thirty pigs were anesthetized and intubated with a cuffed tracheal tube (TT) and an LMA. Then they were assigned to one of five groups. The control group received distilled water 10 mL via the TT; the TT group received epinephrine 50 μg/kg via the TT; and the other three groups received two, four or six times the TT dose of epinephrine via the LMA. Heart rate (HR) and arterial pressure were monitored before and after drug administration for 15 minutes.
Results. After epinephrine administration, the LMA-6 and TT groups had elevated systolic, diastolic and mean arterial pressures at 1 min and there was no significant difference between the two groups. In the TT group, these parameters peaked at 2 min then declined rapidly. In the LMA-6 group, they increased more slowly, and then maintained a plateau. The control, LMA-2 and LMA-4 groups failed to display significant persistent (>2 min) hemodynamic changes.
Conclusions. We could not identify an optimal LMA-administrated epinephrine dose. The TT route is suitable when a high peak drug effect is required and the LMA route may be preferable if a persistent plateau effect is desired. Effective LMA administration of drugs may require larger doses than those given via TT.
Ključne riječi
airway; drug delivery; epinephrine; laryngeal mask airway (LMA); tracheal tube
Hrčak ID:
60052
URI
Datum izdavanja:
1.10.2010.
Posjeta: 1.832 *