Veterinarski arhiv, Vol. 80 No. 5, 2010.
Izvorni znanstveni članak
Therapeutic efficacy evaluation of anthelmintics activity of albendazole and ivermectin drench formulations in donkeys in Darfur, Sudan
Sawsan M. A. Imam
; Department of Medicine, Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Khartoum, Sudan
Hisham I. Seri
orcid.org/0000-0003-3177-1230
; Faculty of Veterinary Medicine, Sudan University of Science and Technology, Sudan
Tigani Hassan
; Department of Medicine, Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Khartoum, Sudan
Tigani A. Tigani
; Faculty of Veterinary Science, University of Nyala, Sudan
Hidaia B. Zolain
; Faculty of Veterinary Science, University of Nyala, Sudan
Adam D. Abakar
orcid.org/0000-0002-4622-1189
; Faculty of Veterinary Medicine, University of Gezira, Sudan
Sažetak
The therapeutic efficacies of albendazole and ivermectin drench formulation at the manufacturer’s recommended dose were evaluated in a controlled trial in Nyala town, South Darfur State, Sudan. The study involved 24 donkeys naturally infected with gastrointestinal nematodes; they were divided into four groups of equal size. Albendazole was administered orally once at a dose rate of 10 mg/kg body mass, or twice, 14 days apart at dose rate of 10 mg/kg body mass. Ivermectin was administered orally as a single dose at 200 μg/kg body mass. Treatment efficacy was based on the mean faecal egg count reduction 14 days post treatment. A faecal egg count reduction of 100% was found after treatment with albendazole and ivermectin. In addition efficacy percentages of albendazole and ivermectin against immature and adult nematodes were as follows: Trichostrongylus axei 67.09% and 100%, Parascaris equorum 100% and 100%, Oxyuris equi 100% and 100%, Strongylus sp. 98.4% and 100%; and small strongyles 100% and 100%. Albendazole single and twice and ivermectin with the single dose showed moderate efficacy (33%, 59.08% and 62.71%, respectively) against larvae found in the cranial mesenteric artery aneurisms. No adverse reactions were observed in treated donkeys during the experiment period.
Ključne riječi
albendazole; donkeys; gastrointestinal nematodes; ivermectin
Hrčak ID:
62145
URI
Datum izdavanja:
26.10.2010.
Posjeta: 2.510 *