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Prevalence and Significance of Vaginal Group B Streptococcus olonization in Pregnant Women from Osijek, Croatia

Andrijana Müller-Vranješ
Dinko Puntarić
Darko Čuržik
Siniša Šijanović
Zlatko Topolovec
Zoran Kasač
Maja Miškulin

Puni tekst: engleski pdf 79 Kb

str. 21-26

preuzimanja: 629



The aim of the study was to determine the prevalence of vaginal group B streptococcus (GBS) colonization in pregnant
women from Osijek area, the possible effect of GBS colonization on pregnancy outcome and neonatal complications and
the role of intrapartum prophylaxis in this context. This retrospective case-control study took place at the Department of
Gynecology and Obstetrics, Osijek University Hospital Center from December 2003 to June 2006. A total of 118 pregnant
women was enrolled in study and divided into two groups: 59 women in 35th–37th week of gestation, free from risk factors
for infection (control group); and 59 women in 25th–41st week of gestation with risk factors for infection. Low vaginal
swab for GBS isolation and identification on selective and enriched medium was obtained from each woman. GBS colonization
was recorded in 29 (24.6%) women: 12 (20.3%) control and 17 (28.8%) women at risk of infection, yielding a statistically
non-significant difference (c
2=1.480489; p<0.48). Early neonatal infection was observed in six (20.7%) neonates
born to 29 mothers with GBS colonization, pointing to a correlation between vaginal GBS colonization and early
neonatal infection (rs=0.99). Early perinatal infection was found in 22 (18.6%) neonates, including 17 (28.8%) pregnancies
with risk factors, pointing to a significant correlation between vaginal GBS colonization, risk factors and early
perinatal infection (c
2=88.68; p<0.001); however, gestational age and pregnancy outcome were not influenced by GBS
colonization. In eight (36.4%) newborns, early neonatal infection developed in spite of intrapartum administration of antibiotics;
three of these children were born to GBS positive mothers, and perinatal GBS infection was demonstrated in
one (0.84%) child. Study results revealed a relatively high rate of GBS colonization in the population of pregnant women
in Croatia, occasionally leading to early neonatal infection. Large studies are needed to develop national strategy for the
prevention of GBS infection in Croatia.

Ključne riječi

group B streptococcus (GBS); pregnancy; neonatal infection; early neonatal group B streptococcal septicemia (ENGBSS); prevention

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