Izvorni znanstveni članak
Predicted Coronary Heart Disease Risk in Croatian HIV Infected Patients Treated with Combination Antiretroviral Therapy
Drago Turčinov
Josip Begovac
Sažetak
We assessed the coronary heart disease (CHD) risk in 130 HIV-infected patients with no major past cardiovascular
event treated with combination antiretroviral therapy (CART) between May 2004 and June 2005. We also investigated
the association of HIV disease parameters (CD4+ T-cell counts, HIV viral load, AIDS diagnosis, antiretroviral medications
and lipodystrophy), demographics, anthropometrics, clinical features, smoking status, dyslipidemia, adherence to
the Mediterranean diet, and the metabolic syndrome (MS) to the Framingham risk score. The median 10-year CHD risk
was 6.4% (IQR 3.3–13.0) for males and 1.8% (IQR 1.0–6.7) for females. The CHD risk was ³10% in 31.1% (32 of 103)
males and in 14.8% (4 of 27) females. MS was present in 27 (20.8%) individuals. Participants who met the definition of
the MS had a 2.63 times greater chance of having a CHD risk ³10% (95% CI, 1.09–6.39; p=0.032). On multivariable
analysis, we found that a CHD risk ³10% was associated with: a lowest ever CD4+ T-cell counts of less than 50 per
microliter and a past history of AIDS (OR, 6.26; 95% CI, 1.61–24.36; p=0.008); alcohol consumption ³10 g/day (OR,
3.87; 95% CI, 1.56–14.22; p=0.041); and age ³43 years (OR, 1.30; 95% CI, 1.17–1.45; p<0.001). Interventions to reduce
the modifiable cardiovascular risk are needed in Croatian patients treated with CART.
Ključne riječi
HIV; coronary heart disease; Framingham risk score; metabolic syndrome
Hrčak ID:
64755
URI
Datum izdavanja:
7.3.2011.
Posjeta: 1.305 *