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Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease

Vesna Herceg-Čavrak
Vladimir Ahel
Maja Batinica
Lana Matec
Danijel Kardoš

Puni tekst: engleski, pdf (78 KB) str. 389-395 preuzimanja: 460* citiraj
APA 6th Edition
Herceg-Čavrak, V., Ahel, V., Batinica, M., Matec, L. i Kardoš, D. (2011). Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease. Collegium antropologicum, 35 (2), 389-395. Preuzeto s https://hrcak.srce.hr/68950
MLA 8th Edition
Herceg-Čavrak, Vesna, et al. "Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease." Collegium antropologicum, vol. 35, br. 2, 2011, str. 389-395. https://hrcak.srce.hr/68950. Citirano 06.03.2021.
Chicago 17th Edition
Herceg-Čavrak, Vesna, Vladimir Ahel, Maja Batinica, Lana Matec i Danijel Kardoš. "Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease." Collegium antropologicum 35, br. 2 (2011): 389-395. https://hrcak.srce.hr/68950
Harvard
Herceg-Čavrak, V., et al. (2011). 'Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease', Collegium antropologicum, 35(2), str. 389-395. Preuzeto s: https://hrcak.srce.hr/68950 (Datum pristupa: 06.03.2021.)
Vancouver
Herceg-Čavrak V, Ahel V, Batinica M, Matec L, Kardoš D. Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease. Collegium antropologicum [Internet]. 2011 [pristupljeno 06.03.2021.];35(2):389-395. Dostupno na: https://hrcak.srce.hr/68950
IEEE
V. Herceg-Čavrak, V. Ahel, M. Batinica, L. Matec i D. Kardoš, "Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease", Collegium antropologicum, vol.35, br. 2, str. 389-395, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/68950. [Citirano: 06.03.2021.]

Sažetak
Survivors of childhood cancer have a significantly higher late morbidity and mortality from cardiovascular diseases.
The aim of this study was to determine whether anthracyclines used in childhood could increase arterial stiffness, a
well-known independent predictor of cardiovascular diseases. The study included 53 children and adolescents aged
6–20 years having completed anthracycline treatment for a malignant disease according to various protocols at least a
year before. The patients were free from clinical or laboratory signs of the underlying disease or cardiac disease. Control
group consisted of 45 age- and sex-matched healthy children. Arterial stiffness was determined by measuring aortic
pulse wave velocity (PWVao) using oscillometric method (Arteriograph TensioMed device). PWVao value was significantly
increased (6.24±1.34 m/s vs. 5.42±0.69 m/s; p<0.001) in patients having received anthracyclines as compared to
control group. Increased arterial stiffness was present irrespective of the following parameters: age, sex, body mass index,
systolic and diastolic blood pressure, mean arterial pressure and heart rate. It is possible that the effect of anthracycline
on increased cardiovascular morbidity and mortality in long-term childhood cancer survivors is associated not
only with cardiotoxicity, but also with increased arterial stiffness.

Ključne riječi
anthracyclines; arteries; drug effects; child; neoplasms; drug therapy; oscillometry

Hrčak ID: 68950

URI
https://hrcak.srce.hr/68950

Posjeta: 689 *