Croatica Chemica Acta, Vol. 84 No. 2, 2011.
Izvorni znanstveni članak
https://doi.org/10.5562/cca1828
Bimetallic Copper-Heme-Protein-DNA Hybrid Catalyst for Diels Alder Reaction
Chi-Hsien Kuo
; Technische Universität Dortmund, Fakultät Chemie, Biologisch-Chemische Mikrostrukturtechnik, Otto-Hahn Str. 6, D-44227 Dortmund; Germany; Institute of Chemistry, Academia Sinica, 128 Academia Road Scc. 2, Nankang, Taipei 11529, Taiwan
Christof M Niemeyer
; Technische Universität Dortmund, Fakultät Chemie, Biologisch-Chemische Mikrostrukturtechnik, Otto-Hahn Str. 6, D-44227 Dortmund, Germany
Ljiljana Fruk
; DFG-Centre For Functional Nanostructures, Karlsruhe Institute of Technology, Wolfgang Gaede Str. 1a, 76131 Karlsruhe, Germany
Sažetak
A bimetallic heme-DNA cofactor, containing an iron and a copper center, was synthesized for
the design of novel hybrid catalysts for stereoselective synthesis. The cofactor was used for the
reconstitution of apo-myoglobin. Both the cofactor alone and its myoglobin adduct were used to catalyze
a model Diels Alder reaction. Stereoselectivity of this conversion was analyzed by chiral HPLC.
Reactions carried out in the presence of myoglobin-heme-Cu-DNA catalyst showed greater product
conversion and stereoselectivity than those carried out with the heme-Cu-DNA cofactor. This observation
suggested that the protein shell plays a significant role in the catalytic conversion.(doi: 10.5562/cca1828)
Ključne riječi
bioorganic chemistry; DNA-protein conjugates; stereoselective catalysis
Hrčak ID:
71990
URI
Datum izdavanja:
3.10.2011.
Posjeta: 2.521 *