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Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas

Dora Fučkar Čupić
Eleonora Cini Tešar
Koviljka Matušan Ilijaš
Johan Nemrava
Marinko Kovačević
Elvira Mustać

Puni tekst: engleski pdf 249 Kb

str. 7-10

preuzimanja: 443



The matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases that are secreted as inactive
precursors, which are activated by cleavage of an N-terminal pro-peptide. Their basic mechanisms of action include
cancer cell growth, differentiation, apoptosis, migration and invasion, and the regulation of tumour angiogenesis and
immune surveillance. The expression of MMP2 and MMP9 has been associated with high potential of metastasis in several
human carcinomas including breast cancer. The 29 female patients, 9 premenopausal and 20 postmenopausal, aged
from 37 to 79 years were included in this study. Tissue samples were examined in 29 primary and 48 recurrent carcinomas
using the tissue microarrays which included 102 cores of primary breast carcinomas and 96 of recurrent breast carcinomas.
Immunohistochemistry determined a pattern of expression for MMP9. The staining was diffuse cytoplasmic,
strong, moderate, faint/weak and negative. The majority of the breast carcinomas stained homogenously for MMP9 on
tumor cells. Statistically significant correlation was found for the expression of MMP9 between primary and recurrent
breast carcinomas in general (p<0.001) and in tumors that were grouped as recurrence before (p=0.039) and after 24
months (p<0.001). Strong expression of MMP9 was observed in primary tumors that recurred after 24 months, median:
162.5 (score range 0–300) and those tumors that recurred before 24 months of the initial diagnosis, median: 102.5 (score
range 0–250) (p=0.026).

Ključne riječi

breast carcinoma; MMP9; primary; recurrent

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