Pregledni rad
Clinical Utility of Red Cell Distribution Width in Alcoholic and Non-alcoholic Liver Cirrhosis
Sandra Milić
Ivana Mikolašević
Mladen Radić
Goran Hauser
Davor Štimac
Sažetak
Red blood cell distribution width (RDW) is a measure of the variation of red blood cell width that is reported as a part
of standard complete blood count. Red blood cell distribution width results are often used together with mean corpuscular
volume (MCV) results to figure out mixed anemia. The aim of our study was to compare the values of RDW in alcoholic
and non-alcoholic liver cirrhosis and to determine if RDW follows the severity of disease according to Child-Pugh
score. We retrospectively analyzed 241 patients (176 men and 65 women) with liver cirrhosis and anemia, defined as a
hemoglobin value <130 g/L in men and <120 g/L in women, which were hospitalized in our Division in a period between
2006 and 2008. Patients were divided in two groups; in first were patients with alcoholic liver cirrhosis, and in second
with non-alcoholic cirrhosis. Severity of disease was determined according to Child-Pugh score. Red blood cells distribution
width Normal reference range is 11–15%. Alcoholic liver cirrhosis had 204 patients (85%) while non-alcoholic cirrhosis
had 37 patients (15%). In group of alcoholic cirrhosis the average RDW was 16.8%. In relation to severity of disease
the average RDW for Child-Pugh A was 16.80%, for Child-Pugh B was 16.92%, for Child-Pugh C was 17.10%. In
the group of non-alcoholic cirrhosis the average RDW was 16.73% and in relation to severity of disease for Child-Pugh A
was 16.25%, for Child-Pugh B 17.01% and for Child-Pugh C was 16.87%. We didn’t find statistically significant difference
of RDW between alcoholic and non alcoholic cirrhosis (p>0.05) and we didn’t proved any statistically significant
increase of RDW in relation to severity of disease in group of alcoholic cirrhosis (p=0.915) nor in group of patients with
non-alcoholic cirrhosis (p=0.697). Our study showed that RDW had not any clinical value in differentiation of anemia
neither in alcoholic and non-alcoholic liver cirrhosis nor in severity of liver disease.
Ključne riječi
red blood cells distribution width; alcocholic cirrhosis; non alcocholic cirrhosis; severity of disease
Hrčak ID:
72304
URI
Datum izdavanja:
25.9.2011.
Posjeta: 1.933 *