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Molecular pathways in cancer-related inflammation

Annalisa Dep Prete   ORCID icon orcid.org/0000-0002-3738-412X ; Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Basic Medical Sciences, University of Bari, Bari, Italy
Paola Allavena ; Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Giuseppe Santoro ; Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy
Ruggiero Fumarulo ; Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy
Massimiliano M. Corsi ; Department of Human Morphology and Biomedical Sciences “Città Studi”, University of Milan, and Soc. Clinical Pathology and IRCCS Policlinico San Donato, Milan, Italy
Alberto Mantovani ; Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Translational Medicine, University of Milan, Milan, Italy

Puni tekst: engleski, pdf (201 KB) str. 264-275 preuzimanja: 1.383* citiraj
APA 6th Edition
Dep Prete, A., Allavena, P., Santoro, G., Fumarulo, R., Corsi, M.M. i Mantovani, A. (2011). Molecular pathways in cancer-related inflammation. Biochemia Medica, 21 (3), 264-275. Preuzeto s https://hrcak.srce.hr/72947
MLA 8th Edition
Dep Prete, Annalisa, et al. "Molecular pathways in cancer-related inflammation." Biochemia Medica, vol. 21, br. 3, 2011, str. 264-275. https://hrcak.srce.hr/72947. Citirano 23.09.2021.
Chicago 17th Edition
Dep Prete, Annalisa, Paola Allavena, Giuseppe Santoro, Ruggiero Fumarulo, Massimiliano M. Corsi i Alberto Mantovani. "Molecular pathways in cancer-related inflammation." Biochemia Medica 21, br. 3 (2011): 264-275. https://hrcak.srce.hr/72947
Harvard
Dep Prete, A., et al. (2011). 'Molecular pathways in cancer-related inflammation', Biochemia Medica, 21(3), str. 264-275. Preuzeto s: https://hrcak.srce.hr/72947 (Datum pristupa: 23.09.2021.)
Vancouver
Dep Prete A, Allavena P, Santoro G, Fumarulo R, Corsi MM, Mantovani A. Molecular pathways in cancer-related inflammation. Biochemia Medica [Internet]. 2011 [pristupljeno 23.09.2021.];21(3):264-275. Dostupno na: https://hrcak.srce.hr/72947
IEEE
A. Dep Prete, P. Allavena, G. Santoro, R. Fumarulo, M.M. Corsi i A. Mantovani, "Molecular pathways in cancer-related inflammation", Biochemia Medica, vol.21, br. 3, str. 264-275, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/72947. [Citirano: 23.09.2021.]

Sažetak
Accumulating evidence shows that chronic inflammation is associated to increased risk of cancer. An inflammatory component is present also in the microenvironment of tumours epidemiologically unre-lated to inflammation. Extensive investigations over the past decade have uncovered many of the important mechanistic pathways underlying cancer-related inflammation. Pathways linking inflamma-tion and cancer have been identified: an intrinsic one (driven by genetic events that cause neoplasia) and an extrinsic one (driven by inflammatory conditions which predispose to cancer). Smouldering inflammation is a component of the tumour microenvironment and is a recognized hallmark of cancer. Key orchestrators at the intersection of the intrinsic and extrinsic pathways include transcription fac-tors (e.g. Nuclear Factor kappa-B, NFκB) that modulate the inflammatory response through soluble mediators (cytokines, chemokines) and cellular components (e.g. tumor-associated macrophages), promoting tumorigenesis. NFκB aids in the proliferation and survival of malignant cells, promotes an-giogenesis and metastasis, subverts adaptive immunity, and alters responses to hormones and che-motherapeutic agents. Emerging evidence also suggests that persistent inflammation promotes ge-netic instability. Thus, cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies.

Ključne riječi
cancer-related inflammation; cytokines; chemokines; macrophages

Hrčak ID: 72947

URI
https://hrcak.srce.hr/72947

Posjeta: 1.791 *