Biological actions of drug solvents
; 1Department of Physiology, School of Medicine, University of Zagreb, Šalata 3b, 10000 Zagreb, Croatia
IVAN ĆAVAR ; Department of Physiology, School of Medicine, University of Mostar, Bijeli brijeg bb, 88 000 Mostar, Bosnia and Herzegovina
FILIP ČULO ; 1_Department of Physiology, School of Medicine, University of Mostar, Bijeli brijeg bb, 88 000 Mostar, Bosnia and Herzegovina; 2_Department of Physiology, School of Medicine, University of Osijek, Huttlerova 4, 31000 Osijek, Croatia
APA 6th Edition
KELAVA, T., ĆAVAR, I. i ČULO, F. (2011). Biological actions of drug solvents. Periodicum biologorum, 113 (3), 311-320. Preuzeto s https://hrcak.srce.hr/74090
MLA 8th Edition
KELAVA, TOMISLAV, et al. "Biological actions of drug solvents." Periodicum biologorum, vol. 113, br. 3, 2011, str. 311-320. https://hrcak.srce.hr/74090. Citirano 18.08.2022.
Chicago 17th Edition
KELAVA, TOMISLAV, IVAN ĆAVAR i FILIP ČULO. "Biological actions of drug solvents." Periodicum biologorum 113, br. 3 (2011): 311-320. https://hrcak.srce.hr/74090
KELAVA, T., ĆAVAR, I., i ČULO, F. (2011). 'Biological actions of drug solvents', Periodicum biologorum, 113(3), str. 311-320. Preuzeto s: https://hrcak.srce.hr/74090 (Datum pristupa: 18.08.2022.)
KELAVA T, ĆAVAR I, ČULO F. Biological actions of drug solvents. Periodicum biologorum [Internet]. 2011 [pristupljeno 18.08.2022.];113(3):311-320. Dostupno na: https://hrcak.srce.hr/74090
T. KELAVA, I. ĆAVAR i F. ČULO, "Biological actions of drug solvents", Periodicum biologorum, vol.113, br. 3, str. 311-320, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/74090. [Citirano: 18.08.2022.]
Many biologic agents are weakly soluble in water. Therefore, they should be dissolved in organic lipophilic solvents (vehicles). A drug vehicle is a substance of no therapeutic value that is used to convey an active biological agent to the site of its action. Ideally, it should be biocompatible, 100% reliable, with no biological effect per se. However, presently used vehicles have pleiotropic effects, which are often unknown to researchers, and often cause misleading conclusions. In this review we summarize data on biological effects
of the three most commonly used lipophilic drug vehicles dimethylsulfoxide (DMSO), propylene glycol (PG) and ethanol. Besides in experimental models, the data, where available, are shown on effects of solvents in therapeutic use in humans. In conclusion, some recommendations are given on the use of drug solvents in experiments.
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