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PSYCHO-SOCIAL AND CLINICAL VARIABLES ASSOCIATED WITH DEPRESSION IN PATIENTS WITH TYPE 2 DIABETES

Žana Stanković ; Clinic for Psychiatry, University in Belgrade, Serbia
Miroslava Jašović-Gašić ; Clinic for Psychiatry, University in Belgrade, Serbia
Miroslava Zamaklar ; Institute for Endocrinology, Diabetes and Diseases of metabolism, University in Belgrade, Serbia

Sažetak

Background: Type 2 diabetes (T2DM) doubles the odds of comorbid depression. Depression is a strong predictor of developing
T2DM. The aim of the study was to compare depressed patients with T2DM to non-depressed ones with respect to demographic,
psycho-social, clinical, anthropometric and metabolic characteristics; to examine the relationship between glycemic control and
depression severity in depressed patients; to estimate the risk factors of depression.
Subjects and Methods: A group of depressed diabetic patients comprising those with a Major depressive episode, first or
repeated (ICD-10; 1992) and endocrinologist-diagnosed T2DM, duration ≥5 years on oral, insulin therapy or both (N=46) and nondepressed
ones (N=44) (90 in total) of both genders (<65 years) were included in this cross-sectional study. Laboratory and nonlaboratory
measures were performed.. The patient Health Questionnaire (PHQ-9) and a structured interview (MINI) were used to
establish diagnosis, while the Beck Depression Inventory (BDI; cut off ≥16) was used to assess the severity ofdepression. Scaling of
Life Events (SLE) for self-assessment of life events and Problem in Areas in Diabetes (PAID) for self-assessment of diabetes distress
were also performed.
Results: Statistically significant higher rates of psychiatric heredity, neuropathy, higher level of diabetes related distress and a
greater number of life events in depressed patients compared to non-depressed ones were found. There was a statistically significant
positive correlation between BDI somatic subscore and the HbA1c level (r=0.343; p=0.020). The level of diabetes related distress
(OR=1.084; p=0.000), total number of life events (OR=4.528; p=0.001) and neuropathy (OR=8.699; p=0.039) were statistically
significant predictors of depression using logistic regression.
Conclusions: The results obtained showed that depression in diabetic patients was predicted by both psychological (diabetes
related distress, life events) and disease-specific variables (neuropathy). The severity of self-reported somatic depressive symptoms
significantly correlated with the HbA1c level in depressed diabetic patients.

Ključne riječi

depression; type 2 diabetes; comorbidity; risk factors; neuropathy; diabetes related distress

Hrčak ID:

76425

URI

https://hrcak.srce.hr/76425

Datum izdavanja:

31.3.2011.

Posjeta: 1.454 *