Veterinary Archives, Vol. 71 No. 1, 2001.
Original scientific paper
Endoscopic evaluation of gastric mucosa after oral administration of ibuprofen in dogs.
Rajah Arunachalam Ramprabhu
; Centre of Advanced Studies in Clinical Medicine and Therapeutics, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Vepery, India
Sethupandian Prathaban
; Centre of Advanced Studies in Clinical Medicine and Therapeutics, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Vepery, India
Ayyanampakkam Pandurangan Nambi
; Centre of Advanced Studies in Clinical Medicine and Therapeutics, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Vepery, India
Balasubramanian Nagarajan
; Centre of Advanced Studies in Clinical Medicine and Therapeutics, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Vepery, India
Periasamy Dhanapalan
; Centre of Advanced Studies in Clinical Medicine and Therapeutics, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Vepery, India
Abstract
Experiments were carried out on 3 groups of dogs in order to evaluate changes in gastric mucosa after oral administration of therapeutic and toxic doses of ibuprofen at the Centre for Advanced Studies in Clinical Medicine and Therapeutics, Madras Veterinary College, Chennai, India. Clinical examination of animals, routine blood profile and endoscopic evaluation of gastric mucosa were carried out on day 5 and day 8 of the experiment. All group II dogs administered with therapeutic doses of ibuprofen evidenced severe congestion of the mucosa on day 5, and small, bleeding ulcers on day 8, upon endoscopic examination. All dogs in group III showed severe signs of haemorrhage on day 5. It was concluded that dogs were more sensitive to ibuprofen than human beings and that it should be used judiciously in animals.
Keywords
dog; ibuprofen; toxicity; endoscopy
Hrčak ID:
83119
URI
Publication date:
18.2.2001.
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