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https://doi.org/10.5562/cca2198

Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction

Luka Krstulović ; Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia
Hamit Ismaili ; Faculty of Mathematics and Natural Sciences, University of Pristina, Agim Ramadani n.n. 10000, Pristina, Kosovo
Miroslav Bajić ; Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia
Aleksandar Višnjevac ; Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia
Ljubica Glavaš-Obrovac ; Department of Clinical Chemistry and Biochemistry, School of Medicine, J. J. Strossmayer University of Osijek, Huttlerova 4, HR-31000 Osijek, Croatia;Clinical Hospital Centre Osijek, Clinical Institute of Nuclear Medicine and Radiation Protection, Huttler
Biserka Žinić orcid id orcid.org/0000-0002-1536-7142 ; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia


Puni tekst: engleski pdf 1.750 Kb

str. 525-534

preuzimanja: 1.442

citiraj


Sažetak

A series of new aliphatic N-sulfonylamidino thymine derivatives containing nucleobase,
N-sulfonyl and amidine pharmacophores in the structure were synthesized by Cu(I)-catalyzed threecomponent
coupling of 1-propargyl thymine, benzenesulfonyl azides and amines or ammonium salts. Preliminary
in vitro antitumor screening (human cervix adenocarcinoma -HeLa and leukemia cells - Jurkat)
revealed promising activities of N,N-diethyl- (2) and N-4-cyanobenzyl- (6) derivatives of 4-acetamidobenzenesulfonyl
amidine. (doi: 10.5562/cca2198)

Ključne riječi

alkynes; azides; copper; nucleobases; N-sulfonylamidine

Hrčak ID:

94451

URI

https://hrcak.srce.hr/94451

Datum izdavanja:

17.12.2012.

Posjeta: 2.274 *